Abaloparatide hmoov

Abaloparatide hmoov CAS 247062-33-5|High Purity PTHrP Analog Peptide Supplier Tuam Tshoj|Ntau dua lossis sib npaug li 98% HPLC

Core Muag Cov Ntsiab Lus

✅ Ntau dua lossis sib npaug li 98% HPLC Purity: Siab -purity Abaloparatide hmoov nrog kev ua haujlwm zoo sib xws.

✅ Kev Koom Tes Tshwj Xeeb Amino Acid: Kev txawj ntse hauv kev sib txuas Aib (alpha-aminoisobutyric acid) ntawm txoj hauj lwm 29 rau kev txhim kho cov qauv kev ruaj ntseg.

✅ Siab Receptor Selectivity: Tsim los rau kev tshawb fawb tsom rau R0 lub xeev ntawm PTH1 receptor kom txhim kho cov lus teb anabolic.

✅ Tuam Tshoj Peptide Chaw tsim tshuaj paus: GMP- kho qhov chaw tsim khoom nrog scalable milligram rau kilogram peev.

✅ Daim Ntawv Qhia Txog Tus Kheej: Txhua pawg tau lees paub los ntawm siab - daws teeb meem LC-MS thiab purity chromatogram.

✅ Ua kom tiav cov ntaub ntawv: Batch- tshwj xeeb COA, HPLC, LC-MS, thiab MSDS muab rau txhua qhov khoom xa tuaj.

Abaloparatide hmoovyog ib qho hluavtaws 34-amino acid peptide analog ntawm tib neeg Parathyroid Hormone-related Protein (PTHrP 1-34). Nws tau tsim tshwj xeeb nrog ntau qhov kev hloov pauv (xws li Glu22, Leu23, Glu25, Lys26, thiab Aib29) txhawm rau ua kom nws ruaj khov thiab xaiv rau PTH1 receptor (PTH1R).

Piv rau cov neeg PTH (1-34), Abaloparatide qhia tau tias muaj kev nyiam tshaj plaws rau lub sijhawm ncua, siab -affinity R0 lub xeev ntawm PTH1R, uas cuam tshuam nrog cov pob txha muaj zog dua- tsim (anabolic) cov lus teb thiab kev pheej hmoo tsawg dua ntawm cov pob txha resorption lossis hypercalcemia ntau dhau {7} qauv. HDM BIO muab lub siab dawb huv peptide no rau lub koom haum tshawb fawb thoob ntiaj teb tsom rau kev mob pob txha, pob txha ntom ntom, thiab cov ntxhia hauv homeostasis.Tshawb nrhiav-tsuas yog kev lees paub: Rau ua ntej- kuaj kuaj kuaj mob nkaus xwb. Tsis yog rau tib neeg siv tshuaj kho mob, kuaj mob, lossis tshuaj.

PebAbaloparatide hmoovkev tsim khoom ua raws li kev tswj hwm Fmoc-SPPS workflow:

1. Chain Elongation: Precise stepwise los ua ke ntawm 34-mer saw, ua kom muaj kev sib txuas ua haujlwm siab rau qhov tsis muaj qhov cuam tshuam Aib residue.
2. Cleavage & Deprotection: Tswj kev tshem tawm ntawm cov resin nrog optimized scavengers los tiv thaiv oxidation ntawm Nws thiab Arg sab chains.
3. RP-HPLC Purification: Multi-theem preparative reverse-phase HPLC kom tshem tawm cov seem thiab cov epimers.
4. Thaum kawg LC-MS Confirmation: Txhua pawg tau txheeb xyuas qhov tseeb kom ntseeg tau tias qhov sib lawv liag thiab kev hloov kho yog raug.
5. Lyophilization: Kev hloov pauv mus rau qhov ruaj khov, cov hmoov soluble heev rau kev hloov kho yooj yim.

Synthesis optimization

Kev suav nrog Aib (alpha-aminoisobutyric acid) yuav tsum muaj kev sib txuas tshwj xeeb (piv txwv li, cov tshuaj tiv thaiv ntev dua lossis muaj zog ua kom muaj zog) kom ntseeg tau 100% hloov dua siab tshiab thiab tiv thaiv kom tsis txhob muaj peptide impurities.

HDM BIO muab kev tshawb fawb-qib Abaloparatide hmoov rau chav kuaj thiab ua ntej- cov ntawv kho mob nkaus xwb.

1. Purity of Building Blocks: Kev siv siab -zoo Fmoc-Aib-OH yog qhov tseem ceeb rau kev tiv thaiv impurities.
2. Kev Txawj Ntse: Muaj peev xwm muab siab - daws teeb meem LC-MS cov ntaub ntawv rau ~ 4kDa peptide.
3. Traceability: Tag nrho cov ntaub ntawv kom ntseeg tau tias txhua batch ua tau raws li qhov loj tshaj los yog sib npaug rau 98% purity specification.
4. Scalability: Kev ua tau zoo ib yam los ntawm cov qauv tshawb fawb milligram mus rau gram- nplai ntau.

• MOQ: Yooj yim; milligram cov qauv thiab cov gram ntau ntau- nplai xaj tau txais kev txhawb nqa.
• Cov Qauv: Cov qauv them nqi kuaj muaj nrog tag nrho cov ntaub ntawv QC rau kev soj ntsuam kuaj.
• Bulk pricing: Tiered pricing qauv; cov ntim loj xa cov nqi sib tw.
• Lub Sijhawm Lead: Cov txheej txheem txheej txheem feem ntau yog nyob rau hauv Tshuag; kev cai synthesis yuav siv sij hawm 3-4 lub lis piam.
• Nqe Lus Nug: Hu rau peb pab neeg muag khoom rau cov lus tshaj tawm tshiab raws li koj qhov kev xav tau purity tshwj xeeb.

1. PTH1 Receptor Pharmacology: Kawm txog kev sib koom ua ke thiab R0 vs RG xeev xaiv.
2. Osteoblast Signaling: Tshawb xyuas cAMP thiab anabolic signaling txoj hauv kev hauv cov pob txha.
3. Bone Density & Microarchitecture: Ua ntej- kev soj ntsuam soj ntsuam hauv tsiaj cov qauv ntawm cov pob txha poob.
4. Endocrine Metabolism Kev Tshawb Fawb: Kawm lub luag haujlwm ntawm PTHrP analogs hauv cov ntxhia hauv homeostasis.
5. Formulation Development: Tshawb nrhiav kev txhawb nqa - tso tawm lossis transdermal xa tshuab rau peptides loj.

Q: CAS tus naj npawb ntawm Abaloparatide hmoov yog dab tsi?
A: CAS Nr .: 247062-33-5.

Q: Puas yog Abaloparatide zoo ib yam li Teriparatide?
A: Tsis yog. Abaloparatide yog ib qho piv txwv ntawm PTHrP (1-34) nrog kev hloov kho xws li Aib29, thaum Teriparatide yog ib feem ntawm PTH (1-34).

Q: Kuv puas tuaj yeem yuav Abaloparatide hmoov los ntawm Tuam Tshoj?
A: HDM BIO yog cov kws tshaj lij peptide chaw tsim khoom hauv Suav teb muab siab -purity Abaloparatide thoob ntiaj teb.

Q: Yuav khaws cov hmoov li cas?
A: Khaws kaw ntawm -20 degree, tiv thaiv lub teeb thiab noo noo. Rau kev khaws cia ntev, -80℃pom zoo.

Q: Dab tsi yog qhov purity ntawm koj Abaloparatide?
A: Peb qhov kev tshawb fawb tus qauv- qib purity yog ntau dua lossis sib npaug li 98% HPLC.

Peb muab ib qho kev tshaj lij - nres kev yuav khoom thiab kev txhawb nqa rau ntiaj teb peptide R&D cov haujlwm:

• Batch - tshwj xeeb COA
• MSDS Safety Data Sheet
• Cov ntaub ntawv pov thawj GMP & ISO
• Custom Bulk Lag luam wholesale Nqe
• Cov qauv dawb muaj
• Dedicated Technical Formulation Support

Thov COA Tau Txais Tus Nqi Them Nqi Thov Tus Qauv

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