Plecanatide hmoov CAS 467426-54-6|Ntau dua lossis sib npaug li 98% HPLC Chaw Tsim Tshuaj Tuam Tshoj

Core Muag Cov Ntsiab Lus

✅ Ntau dua lossis sib npaug li 98% HPLC Purity: Siab -purity Plecanatide hmoov nrog lav kev ntseeg siab.

✅ Precise Disulfide Folding: Cov kws tshaj lij tswj hwm ntawm Cys4-Cys12 thiab Cys7-Cys15 ua ke, qhov tseem ceeb rau GC-C receptor activation.

✅ pH-Sensitive Stability: Optimized rau kev tshawb fawb txog plab hnyuv pH-nyob ntawm bioactivity.

✅ Tuam Tshoj Peptide Chaw Tsim Tshuaj: GMP- ua raws li cov chaw tsim khoom tshwj xeeb hauv kev sib tw cyclic GI peptides.

✅ Kev Ntsuas Tus Kheej: Txhua pawg tau lees paub los ntawm siab - daws teeb meem LC-MS thiab purity chromatogram.

✅ Ua tiav Cov Ntaub Ntawv: Kev txhawb nqa tag nrho rau kev kuaj sim, suav nrog COA, MSDS, thiab kev tshem tawm tawm.

Plcanatide Powder yog dab tsi?

Plecanatide hmoovyog ib qho hluavtaws 16-amino acid peptide analog ntawm tib neeg uroguanylin. Nws ua haujlwm raws li lub zog agonist ntawm Guanylate Cyclase-C (GC{5}}C) receptors nyob rau ntawm qhov chaw luminal ntawm plab hnyuv enterocytes. Kev ua kom muaj GC-C ua rau muaj kev nce hauv intracellular cyclic guanosine monophosphate (cGMP), uas txhawb nqa cov tshuaj chloride thiab bicarbonate rau hauv plab hnyuv lumen, thaum kawg ua rau plab hnyuv thiab ua kom nrawm dua.

Synthesizing Plecanatide yuav tsum tau sophisticated oxidative folding cov tswv yim los xyuas kom meej ob disulfide txuas hniav yog tsim nyob rau hauv qhov tseeb orientation. HDM BIO siv ntau- kauj ruam purification lub tswv yim los tshem tawm cov isomers misfolded thiab truncated sequences, muab ib tug siab - purity raw khoom rau ua ntej - kev tshawb fawb soj ntsuam nyob rau hauv chronic idiopathic constipation (CIC) thiab chim siab plob tsis so tswj syndrome (IBS).

Tshawb nrhiav-tsuas yog kev lees paub: Rau ua ntej- kuaj kuaj kuaj mob nkaus xwb. Tsis yog rau tib neeg siv tshuaj kho mob, kuaj mob, lossis tshuaj.

Dab tsi yog Cov Lus Qhia Zoo?

Yam khoom	Specification	Kev tshwm sim
Qhov tshwm sim	Dawb rau tawm -dawb hmoov	Zoo ib yam
Purity (HPLC)	Ntau dua lossis sib npaug li 98%	99.96%
MS Identity	Raws li tus qauv siv	Kev lees paub
Xaus	Cosmetic raw khoom xav tau	Dhau

Plecanatide vs Linaclotide: Dab tsi yog Qhov txawv?

Peptide	Amino Acids	Disulfide Bridges	Kev Tshawb Fawb Tseem Ceeb
Plecanatide	16 UA	2 Tus choj	pH{0}}sensitive GC-C agonist
Linaclotide	14 UA	3 Tus choj	Muaj peev xwm GC-C agonist (nruj dua)

Plecanatide Ua li cas?

PebPlecanatide hmoovkev tsim khoom tsom rau folding precision:

Khoom Phase Assembly: Stepwise synthesis ntawm 16-mer linear saw siv siab-zoo Fmoc-tiv thaiv amino acids.
Direction Folding: Siv cov kev tiv thaiv orthogonal cysteine los yog optimized redox- tsis siv tshuab los tsav kev tsim ntawm 4-12 thiab 7-15 disulfide bonds.
RP-HPLC Purification: Multi-theem npaj HPLC kom cais cov peptide kom raug los ntawm cov isomers tsis ua haujlwm.
Lyophilization: Hloov mus rau hauv ib qho ruaj khov, cov hmoov soluble heev nyob rau hauv kev tswj kub thiab lub tshuab nqus tsev.
Kev txheeb xyuas qhov tseeb: QC kawg suav nrog HPLC purity check thiab LC-MS kev pom zoo.

Isomer & Impurity Tswj

Qhov kev sib tw loj hauv Plecanatide synthesis yog tsim ntawm "scrambled" isomers. HDM BIO siv cov txheej txheem ua kom huv huv los xyuas kom meej cov qauv ntawm txhua pawg.

Qhov txawv ntawm Kev Tshawb Fawb Qib thiab Pharmaceutical Qib Plecanatide yog dab tsi?

Qeb	Qib tshawb fawb	Pharmaceutical Qib
Lub Hom Phiaj	Ua ntej- kev tshawb fawb soj ntsuam / Lab	Pom zoo tsim tshuaj
Cov ntaub ntawv	COA / HPLC / LC-MS / MSDS	Tag Nrho GMP / Regulatory Dossier
Daim ntawv thov	Hauv -vitro / Tsiaj R&D	Tib neeg cov tshuaj (xws li Trulance)
Supply Channel	Tshwj xeeb R & D cov neeg muab khoom	Daim ntawv tso cai API Manufacturers

HDM BIO muab kev tshawb fawb-qib Plecanatide hmoov rau chav kuaj thiab ua ntej- cov ntawv kho mob nkaus xwb.

Vim li cas tus neeg muab khoom tsim nyog tseem ceeb ua ntej yuav Plecanatide?

Folding Expertise: Kev txheeb xyuas qhov tseeb ntawm tus choj disulfide yog qhov tseem ceeb rau bioactivity.
Analytical Transparency: Cov neeg muag khoom ntseeg tau muab HPLC thiab LC kom meej -MS cov ntaub ntawv rau txhua pawg.
Scale-Txhim Kho Kom Zoo: Ua kom cov txheej txheem huv huv tuaj yeem rov ua dua los ntawm gram mus rau kilogram nplai.
Kev Pabcuam Kev Tswjhwm: Muaj MSDS thiab cov ntaub ntawv thev naus laus zis rau kev soj ntsuam kev nyab xeeb thiab xa tawm.

Plecanatide Powder Nqe & Daim Ntawv Qhia Ntau Yam 2026

MOQ: Yooj yim; milligram cov qauv thiab ntau gram- nplai xaj muaj.
Qauv: Them cov qauv kuaj nrog tag nrho cov ntaub ntawv QC rau kev soj ntsuam kuaj.
Tus nqi ntau: Tus nqi sib tw sib tw rau - cov haujlwm tshawb fawb loj.
Lub Sijhawm Lead: Cov khoom lag luam txheem xa tuaj hauv 3-5 hnub; kev cai batch nkoj hauv 3-4 lub lis piam.
Nqe Lus Nug: Hu rau peb pab neeg muag khoom rau cov lus tshaj tawm tshiab raws li koj qhov kev xav tau purity.

Vim li cas thiaj xaiv HDM BIO ua koj tus neeg muag khoom?

Cov kws tshaj lij Cyclic Peptide: Tshaj 10 xyoo ntawm kev paub hauv ntau -disulfide choj peptide synthesis.
High-Resolution Purification: Ntau dua lossis sib npaug rau 98% purity tau lees paub los ntawm RP siab heev-HPLC.
Kev Ntsuas Tus Kheej Tsis Txaus: Txhua pawg ua tiav LC-MS lees paub tus kheej.
Ntiaj teb no Shipping Support: Exported mus rau 70+ lub teb chaws nrog tag nrho cov kev lis kev cai - npaj cov ntaub ntawv.
Flexible Customization: Muaj peev xwm muab cov ntawv ntsev kev cai lossis qib purity siab dua thaum thov.

Dab tsi yog Daim Ntawv Thov Kev Tshawb Fawb Tseem Ceeb?

GC-C Receptor Pharmacology: Kawm txog kev sib koom ua ke thiab ua kom muaj zog ntawm guanylate cyclase-C.
Kev tswj cov kua dej hauv plab: Tshawb xyuas cov txheej txheem ntawm cGMP-kev sib haum xeeb ion thiab dej tso tawm.
pH-Dependent Bioactivity: Tshawb xyuas seb luminal pH cuam tshuam li cas peptide stability thiab receptor kev sib cuam tshuam.
Gastrointestinal SAR Studies: Cov qauv- kev tshawb fawb txog kev sib raug zoo piv rau uroguanylin analogs.
Novel Delivery Systems: Txhim kho qhov ncauj formulations los yog lub hom phiaj tso technologies rau GI peptides.

Cov Lus Nug Feem Ntau Txog Plecanatide Hmoov

Q: CAS tus naj npawb ntawm Plcanatide hmoov yog dab tsi?
A: CAS Nr .: 467426-54-6.

Q: Koj Plecanatide puas muaj cov nyiaj disulfide tiag?
A: Yog lawm, peb siv oxidative folding los xyuas kom meej cov choj Cys4-Cys12 thiab Cys7-Cys15 raug tsim.

Q: Kuv tuaj yeem yuav Plecanatide hmoov los ntawm Tuam Tshoj qhov twg?
A: HDM BIO yog cov kws tshaj lij peptide chaw tsim khoom hauv Suav teb muab siab -purity Plecanatide thoob ntiaj teb.

Q: Yuav khaws cov hmoov li cas?
A: Khaws kaw ntawm -20 degree, tiv thaiv lub teeb thiab noo noo. Rau kev khaws cia ntev, -80℃pom zoo.

Q: Dab tsi yog qhov purity ntawm koj Plecanatide?
A: Peb qhov kev tshawb fawb tus qauv- qib purity yog ntau dua lossis sib npaug li 98% HPLC.