Fezolinetant hmoov CAS 1629229-37-3｜High Purity Ntau dua lossis sib npaug li 99% rau Menopausal Hot Flushes Research
Cov txiaj ntsig tseem ceeb:
● Tsis yog -hormonal API rau kub flashes thiab hmo ntuj tawm hws tshuaj R&D
● High chiral purity, tsawg impurities thiab ruaj khov batch sib xws
● GMP-ua raws li cov txheej txheem kev xeem cov ntaub ntawv
● Zoo tagnrho rau kev tsim kho kev tsim kho thoob ntiaj teb thiab kev tshawb fawb tshawb fawb
Product Overview
Fezolinetant hmoovrau kev tshawb fawb-qib, preclinical, thiab kho qhov ncauj formulation kev loj hlob (CAS: 1627710-34-8) yog ib hom phiaj NK3 receptor antagonist API dav siv nyob rau hauv non-hormonal menopause vasomotor tsos mob R&D. Raws li ib qho kev xaiv neurokinin 3 (NK3) receptor antagonist, nws muaj cov qauv tshuaj lom neeg ruaj khov, ib qho kev teeb tsa chiral, thiab cov khoom siv physicochemical ua raws li cov qauv tsim ntawm qhov ncauj.
Fezolinetant Powder pab cov tuam txhab tshuaj thoob ntiaj teb, CROs, cov chaw soj ntsuam kev kawm, thiab hla - ciam teb muag tshuaj. Nrog rau kev tsim cov tshuaj lom neeg paub, kev sib cais chiral, thiab cov txheej txheem recrystallization, nws ua tau raws li ICH API cov qauv zoo. Cov hmoov tuaj yeem siv tau thaum ntxov -theem preclinical thiab pilot kev tshawb fawb, kev tshuaj xyuas qhov ncauj, tshuaj, tshuaj toxicology, thiab pharmacokinetics kev tshawb fawb, muab kev tshawb fawb ruaj khov thiab tshawb nrhiav tau-qib raw khoom rau tsis yog-hormonal menopause vasomotor cov tsos mob tshuaj txhim kho.
COA
| Yam khoom | Specification | Kev tshwm sim | |
| Qhov tshwm sim | Dawb los yog tawm -dawb hmoov. | Dawb hmoov | |
| Solubility | Qhia | Soluble hauv acetonitrile, me ntsis soluble hauv dej. | |
| NMR | Tus'HNMR thiab¹³C NMR spectra yuav tsum sib haum nrog cov qauv | Lub'HNMR thiab¹³C NMR spectra yog concordant nrog cov qauv. | |
| IR | IR spectrum yuav tsum sib haum nrog cov qauv. | IR spectrum yog concordant nrog cov qauv. | |
| MS | MS spectrum yuav tsum sib haum nrog cov qauv. | MS spectrum yog concordant nrog cov qauv. | |
| Lwm tus neeg impurity Tsawg dua lossis sib npaug li 0.10% | 0.05% | ||
| Tag nrho impurities Tsawg dua lossis sib npaug li 1.0% | 0.09% | ||
| Enantiomer | Tsawg dua lossis sib npaug li 0.15% | Tsis pom | |
| Residue ntawm Ignition | Tsawg dua lossis sib npaug li 0.1%. | Tsis pom | |
| Dej | Tsawg dua lossis sib npaug li 0.5% | 0.31% | |
| Crystal Form | XRD spectrum ntawm cov qauv yuav tsum sib haum mus rau qhov uas siv lead ua daim ntawv. | XRD spectrum ntawm cov qauv sib raug rau cov ntawv siv lead ua | |
| Tapped Ceev | Qhia | 0.66 g / ml | |
| Microbial txwv | Qhia | TAMC<100 cfu/g | |
| TYMC<10 cfu/g | |||
| Pseudomonas aeruginosa: tsis nyob hauv 1g Staphylococcus aureus: tsis nyob hauv 1g |
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| Salmonella spp: tsis nyob hauv 1g | |||
| Escherichia coli: tsis nyob hauv 1g | |||
| Assay | 98.0%-102.0% | 99.60% | |
| Xaus | Cov khoom ua raws li cov lus qhia. | ||
Mechanism ntawm Action
Lub ntsiab mechanism ntawm Fezolinetant Powder yog xaiv antagonism ntawm NK3 receptors. Thaum cev xeeb tub, estrogen poob qis cuam tshuam rau hypothalamic{2}}pituitary- kev tswj hwm ntawm zes qe menyuam, ua rau ntau tshaj neurokinin B secretion thiab overactivation ntawm central NK3 receptors. Qhov no rhiab heev rau lub chaw thermoregulatory, ua rau kub flashes, hmo ntuj tawm hws, thiab palpitations. Fezolinetant Powder rau kev tshawb fawb- qib qhov ncauj tsim thiab preclinical R&D khi tshwj xeeb rau NK3 receptors, thaiv cov neurokinin B signaling, stabilizing thermoregulatory rhiab heev, thiab txhim kho menopause vasomotor cov tsos mob. Tsis zoo li kev kho cov tshuaj hormones, nws ua rau txoj hauv kev tsis zoo rau kev siv cov tshuaj hormones, muab cov khoom tshiab uas tsis yog{10}}hormonal raw khoom rau kev tsim tshuaj.
Cov khoom siv
Fezolinetant hmoovrau kev tshawb fawb-qib, tsis yog-hormonal formulation kev loj hlob tuaj yeem siv rau:
￭ Preclinical and pilot-scale development of non-hormonal formulations for menopause vasomotor tsos.
￭ Toxicology, pharmacokinetics, thiab pharmacology tshawb fawb ntawm NK3 receptor pathways thiab poj niam endocrine noj qab haus huv.
￭ Kev tshawb fawb thiab kev tsim kho tshiab uas tsis yog - cov tshuaj hormonal sib tw rau kev laus.
￭ Pharmaceutical intermediate rau hla-kev lag luam ciam teb, txhawb kev tswj hwm- ua raws li thoob ntiaj teb R&D cov haujlwm.
￭ Kev tshawb fawb ntawm neural receptor pharmacology thiab menopause pathology mechanisms.
Cov txiaj ntsig ntawm Fezolinetant Powder
￭ Muaj peev xwm tiv thaiv -Vasomotor Effects: Blocks qhov txawv txav neurokinin B signaling, txo qis kev hnov mob hauv qhov chaw hypothalamic thermoregulatory, txo qis kub flash thiab hmo ntuj tawm hws, thiab txhawb kev ua haujlwm tsis zoo -hormonal menopause cov tsos mob.
￭ Lub Hom Phiaj Siab Tshwj Xeeb: Ua raws nraim ntawm lub hauv paus paj hlwb lub hom phiaj, txo qis - phiaj xwm CNS qhov tsis zoo.
￭ Stable Bioavailability: Optimized molecular qauv txhim kho txoj hnyuv nqus, txo cov ntshav plasma concentration fluctuations, xyuas kom meej cov tshuaj pharmacological zoo ib yam, thiab txo qis kev sim lossis tsim kev pheej hmoo.
￭ Chemical and Physical Stability: Resistant to hydrolysis thiab oxidation, haum rau ntev - tshawb fawb thiab scalable ntau lawm.
Core Zoo
￭ Mature Target Mechanism: NK3 receptor antagonism tau kuaj pom zoo thiab ua raws li cov kev xav hauv ntiaj teb no hauv kev kho tsis yog -hormonal menopause.
￭ Stable Chiral thiab Purity Profile: Standardized chiral sib cais kom ntseeg tau tias tsawg batch -rau -batch variability.
￭ Flexible Supply: Ntau yam kev xaiv ntim, txhawb nqa tus qauv, me me, thiab nruab nrab - nplai xaj.
￭ Mature Hla-Kev Xa Mus Los: Kev xa tawm tag nrho rau kev xa khoom thoob ntiaj teb.
￭ Txhim khu kev ntseeg tau ntev- Lub Sijhawm Muab Khoom: Scalable ntau lawm ua kom cov khoom txaus txaus, zam kev cuam tshuam hauv R & D sijhawm.
Quality Assurance
￭ Tag Nrho- Txheej Txheem GMP: Los ntawm cov khoom siv raw, kev sib txuas, kev sib cais, chiral sib cais, mus rau qhov kawg ntim, txhua pawg tau txais HPLC, chiral purity, noo noo, impurity, thiab kev kuaj pom.
￭ Strict Impurity Management: Organic impurities, residual solvents, hnyav hlau, thiab isomers ua raws li ICH txwv.
￭ Ua kom tiav Batch Traceability: Txhua batch yog tus lej cim, taug qab hla ntau lawm, kuaj, thiab xa khoom.
￭ Kev Cia Siab: Tsis tshua muaj kub, lub teeb- tiv thaiv, ya raws- pov thawj khaws cia khaws cov khoom siv hluav taws xob.
￭ Tom qab- Kev Txhawb Kev Muag Khoom: Cov ntaub ntawv raw cov ntaub ntawv kev sab laj, kev txhais lus tshwj xeeb, thiab cov txheej txheem qhia.
FAQ
Q1: Fezolinetant Powder yog dab tsi?
A: Ib qho kev xaiv NK3 receptor antagonist rau menopause vasomotor cov tsos mob xws li kub flashes thiab hmo ntuj tawm hws.
Q2: Nws ua haujlwm li cas?
A: Thaiv NK3 receptors ntawm hypothalamic GnRH neurons los tswj luteinizing hormone secretion, txo cov tsos mob vasomotor los ntawm kev hloov pauv tshuaj estrogen.
Q3: Fezolinetant Powder puas tuaj yeem siv ncaj qha rau kev tsim khoom lag luam?
A: Nws yog ib qho kev tshawb fawb -qib API haum rau thaum ntxov- theem kev sim thiab kev tshawb fawb tshuaj. Kev siv coj mus muag yuav tsum muaj kev tswj hwm - ua raws API thiab cov ntaub ntawv.
Q4: Puas yog purity lossis chiral specification tuaj yeem kho tau?
A: Yog lawm, cov lus qhia tshwj xeeb tuaj yeem ua raws li qhov xav tau ntawm qhov project, txhawb kev tsim cov qauv sib txawv.
Hoobkas
Daim ntawv pov thawj
Shipping & Packing
Hu rau & Orders
Fezolinetant hmoovrau kev tshawb fawb-qib, tsis yog-hormonal formulation txoj kev loj hlob txhawb nqa lub cev muaj zog physicochemical zog, nruj zoo tswj, ua tiav cov ntaub ntawv, thiab saj zawg zog mov, ua kom muaj txiaj ntsim thoob ntiaj teb cov tsos mob vasomotor R&D. Tiv tauj peb rau tus nqi, cov qauv thov, COA cov ntaub ntawv, lossis cov kev cai muab kev daws teeb meem.Muaj rau kev xa khoom thoob ntiaj teb nrog tus nqi sib tw, GMP ntawv pov thawj thiab cov khoom siv taug qab rau cov chaw tshawb fawb thoob ntiaj teb.
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