Estradiol Valerate API rau Preclinical R & D|Pharmaceutical-Qib Estradiol Valerate rau Oral & Injectable Formulation Development|High-Purity & GMP-Ua raws li cov khoom siv
Cov ntsiab lus tseem ceeb
●Ntev -cov khoom siv tshuaj estrogen
●Lipophilicity zoo heev & ruaj khov siab purity
●Pharmaceutical formulation -qib estrogen API
●nruj impurity tswj
●Haum rau qhov ncauj thiab txhaj tshuaj formulation kev txhim kho daim ntawv thov
Product Overview
Estradiol Valerate API rau kev tshawb fawb preclinical thiab ntev -kev tsim cov tshuaj estrogen formulation yog ib tug valerate ester derivative ntawm estradiol, thiab yog ib tug dav siv tshuaj -qib hluavtaws estrogen raw khoom haum rau HRT, qhov ncauj formulations, thiab roj-raws li R&D.
Tsim los siv cov cuab yeej siv tshuaj lom neeg paub zoo, cov tshuaj no -qib Estradiol Valerate Powder nta lipophilicity zoo heev thiab muab kev tso tawm ntawm cov tshuaj estradiol tom qab nkag mus rau hauv lub cev, ua kom muaj cov tshuaj hormones ruaj khov uas tsis muaj qhov hloov pauv loj. Nws yog qhov tsim nyog rau kev txhawb nqa - tso tawm qhov ncauj thiab txhaj tshuaj tsim tawm, preclinical R&D, thiab kev tsim tshuaj nruab nrab.
Cov khoom no yog tsim los ntawm nruj ua raws li GMP cov qauv kev tsim tshuaj, nrog kev tswj xyuas kom zoo dua purity, muaj feem xyuam rau cov kuab tshuaj, cov khoom hnyav, cov hlau hnyav, thiab lwm yam kev ntsuas zoo. Batch sib xws tseem ruaj khov, thiab cov khoom lag luam feem ntau yog muab rau cov tuam txhab lag luam txawv teb chaws, cov chaw tshawb fawb biopharmaceutical, thiab cov lag luam tshuaj zoo.
COA
| Yam khoom | Specification | Kev tshwm sim | |
| Yam ntxwv | Dawb crystalline hmoov; Tsis hnov tsw. | Ua raws | |
| Solubility | Soluble hauv castor roj, hauv methanol, hauv benzyl benzoate thiab hauv dioxane; sparingly soluble nyob rau hauv sesame roj thiab txiv laum huab xeeb; xyaum insoluble hauv dej. | Ua raws | |
| Kev txheeb xyuas | A: Kev kuaj xyuas infrared qhia tau hais tias lub sijhawm khaws cia ntawm lub ncov tseem ceeb yog ua raws li cov khoom tswj kev ua haujlwm. B: Lub sijhawm khaws cia ntawm lub ncov loj ntawm cov qauv kev daws teeb meem sib raug rau qhov kev daws teeb meem, raws li tau txais hauv Kev Tshawb Fawb. |
Ua raws | |
| Kev sib hloov tshwj xeeb | +41 ~ +47 degree | +43.8 degree | |
| Kev txiav txim siab dej | Tsawg dua lossis sib npaug li 0.1% | 0.03% | |
| Dawb acid cov ntsiab lus | Qhia tawm raws li valeric acid, Tsawg dua lossis sib npaug li 0.5%. | 0.07% | |
| Organic impurities RRT0.1 Estradiol RRT0.9 Estradiol-9-ene valerate RRT1.3 4-Methylestradiol valerate RRT1.7 Estradiol divalerate Txhua tus neeg tsis paub meej impurity Tag nrho impurities |
Tsawg dua lossis sib npaug li 0.2% Tsawg dua lossis sib npaug li 0.2% Tsawg dua lossis sib npaug li 0.4% Tsawg dua lossis sib npaug li 0.15% Tsawg dua lossis sib npaug li 0.10% |
0.09% |
|
| Residue ntawm ignition | Tsawg dua lossis sib npaug li 0.2% | 0.05% | |
| Residual Solvents Methanol Dichloromethane |
Tsawg dua lossis sib npaug li 0.20% Tsawg dua lossis sib npaug li 0.20% |
220 ppm ua Tsis pom |
|
| Assay | 98.0~102.0% | 100.20% | |
| Micron | 100% Tsawg dua lossis sib npaug li 20μm | 100% Tsawg dua lossis sib npaug li 20μm | |
| Xaus | Cov khoom ua raws li cov cai ntawm USP Standard. | ||
Mechanism ntawm Action
Estradiol Valerate hmoov, raws li ib tug prodrug rau kev tshawb fawb preclinical, maj mam tso tawm active 17 -estradiol, muab ntev- ua estrogen muaj rau HRT, kev tshawb fawb endocrine, thiab formulation kev tshawb fawb. Cov valerate sab saw ho txhim kho lipophilicity thiab ncua lub sijhawm ntawm kev ua hauv vivo.Tom qab nkag mus rau hauv lub cev, nws yog hydrolyzed los ntawm esterases nyob rau hauv cov ntshav thiab cov ntaub so ntswg, tshem tawm cov valerate pab pawg neeg thiab tso biologically active estradiol. Active estradiol tshwj xeeb khi rau cov tshuaj estrogen receptors ER thiab ER, yog li tswj cov cell proliferation, sib txawv, thiab metabolism los ntawm kev hloov pauv ntawm cov noob caj noob ces.Nws exerts estrogenic physiological teebmeem ntawm ntau cov ntaub so ntswg thiab kabmob, xws li:
● Txhawb nqa kev ua haujlwm ntawm kev ua me nyuam hauv kev kawm preclinical
● Khaws cov pob txha ceev thiab cov metabolism hauv cov qauv kev tshawb fawb
● Tswj lipid metabolism thiab vascular muaj nuj nqi rau preclinical R & D
● Txhawb kev ncaj ncees ntawm daim tawv nqaij thiab collagen metabolism hauv kev tshawb fawb ntev -
● Tiv thaiv kev hloov pauv ntawm cov tshuaj hormones sai, ua kom muaj kev ruaj ntseg - tso tawm kev tsim khoNws cov qauv ester pab txo qis qhov kev hloov pauv ntawm cov tshuaj hormones sai uas cuam tshuam nrog luv luv - ua estradiol, ua kom ruaj khov thiab txhawb nqa kev tswj hwm endocrine.
Cov khoom siv
Daim ntawv thov ntawm Estradiol Valerate Powder rau Preclinical R&D thiab Ntev -Kev Txhim Kho Kev Ua Haujlwm:
● Cov khoom siv tseem ceeb rau cov tshuaj estrogen hauv qhov ncauj thiab ntev - ua cov tshuaj txhaj tshuaj hauv cov kev tshawb fawb ua ntej
● HRT- cuam tshuam txog kev tshawb fawb tshuaj tshiab, kev tshuaj ntsuam xyuas, thiab kev ntsuas kev ruaj ntseg
● Kev tshawb fawb hauv cov tshuaj tua menyuam, endocrinology, thiab kws tshuaj hauv tsev kawm qib siab thiab biopharma labs
● Kev lag luam tawm txawv teb chaws, kev lag luam tshuaj lom neeg zoo, thiab cov khoom siv R&D customized
● Cov khoom siv rau kev sim tshuaj thiab kev sim-cov haujlwm tshawb fawb rau cov tuam txhab biopharmaceutical
Cov lus qhia ntxaws
Raws li physiological regulatory mechanism ntawm estrogen kev ua si,Estradiol Valerate hmoovtso tawm nquag estradiol los ntawm hauv vivo metabolism, muab me me thiab ntev - ua haujlwm endocrine tswj. Tag nrho cov lus piav qhia txog kev ua tau zoo yog lub hom phiaj, nruj, thiab txhawb nqa los ntawm kev tshawb fawb endocrinology xaus:
● Txhawb cov tshuaj estrogen supplementation thiab preclinical endocrine kev tshawb fawb: Pab txhim kho endocrine imbalance txuam nrog estrogen deficiency thiab tswj cov tshuaj hormones nyob rau hauv sustained -tso kev tshawb fawb
● Txhawb nqa lub cev lub cev ntawm tus poj niam cev xeeb tub thiab pab tswj kev ua haujlwm ntawm endometrial thiab zes qe menyuam.
● Kev txhawb nqa pob txha noj qab haus huv hauv preclinical R&D: tswj cov pob txha metabolism, ua kom cov pob txha tsis muaj zog, tswj cov pob txha zoo li qub, thiab txhawb nqa ntev -cov qauv kev kawm endocrine
● Kev tswj cov metabolism hauv daim tawv nqaij rau kev tshawb fawb preclinical: Txhawb collagen synthesis, lipid metabolism, thiab ruaj khov ntawm daim tawv nqaij physiology hauv formulation thwmsim
● Kev txhawb nqa plawv hauv cov qauv kev tshawb fawb: Modulates lipid metabolism thiab vascular muaj nuj nqi rau preclinical R&D thiab HRT formulation kev tshawb fawb
● Tsim nyog rau kev kho cov tshuaj hormones hloov-txoj kev tshawb fawb, muab cov khoom siv ruaj khov rau cov endocrine- kev tswj hwm kev tsim kho tshuaj
Core Zoo
● Mob me thiab ntev - ua yeeb yam tshuaj estrogen tso tawm rau kev tsim R&D: Cov pab pawg valerate ester txhim kho lipophilicity, slows metabolic degradation hauv vivo, thiab txhawb kev txhawb nqa -tso tawm cov tshuaj tsim tshuaj, tso cai rau cov tshuaj hormones ruaj khov nrog lub sijhawm ntev ntawm kev ua, ua rau nws tsim nyog rau kev loj hlob ntev -
● Kev ruaj khov thiab tswj tau purity: HPLC purity tsis tu ncua tseem muaj ntau dua lossis sib npaug li 99.0%, thaum hom impurity thiab cov ntsiab lus raug tswj nruj kom ua tau raws li cov qauv kev siv tshuaj raw khoom txawv teb chaws.
● Formulation-phooj ywg API rau qhov ncauj thiab txhaj tshuaj R&D: Qhov zoo tshaj plaws lipophilicity ua kom haum rau cov ntsiav tshuaj ntawm qhov ncauj, roj-raws li cov tshuaj txhaj, thiab ntev- ua cov ntawv thov kev tshawb fawb estrogen
● Batch-Ua raws li Estradiol Valerate API rau preclinical thiab industrial R&D: Standardized synthesis thiab QC txo qis physicochemical variations, kom ntseeg tau tias reproducible ntev - ua formulation kev loj hlob
● Cov kev daws teeb meem yooj yim: Txhawb me me -cov qauv kev yuav khoom thiab loj- ntim cov khoom ntim, ua tau raws li qhov sib txawv ntawm kev tshawb fawb hauv chav kuaj thiab kev lag luam- nplai ntau lawm
Quality Assurance
● Tsim los siv siab -purity pib cov ntaub ntawv nyob rau hauv cov txheej txheem huv huv rhiav nrog tag nrho cov txheej txheem ntau lawm
● Txhua batch tau txais kev sim ua tiav, suav nrog HPLC kev tshuaj xyuas, qhov taw tes melting, noo noo, hnyav hlau, thiab lwm yam tshuaj, nrog rau cov ntaub ntawv tshaj tawm COA
● Cov xwm txheej ntawm daim ntawv thov raug txwv nruj rau tib neeg kev tshawb fawb tshuaj thiab kev tsim khoom lag luam kom tsis txhob muaj kev pheej hmoo cuam tshuam nrog kev siv tsis raug-
● Cov neeg siv khoom kuaj cov qauv tau txais kev txhawb nqa, thiab cov khoom lag luam loj tseem nyob nrog cov qauv zoo kom ntseeg tau tias kev ruaj ntseg
● Ua tiav cov ntaub ntawv xa tawm tuaj yeem ua raws li cov cai tswj kev lis kev cai hauv ntau lub tebchaws thoob ntiaj teb
FAQ
Q1: Cov tshuaj no puas tuaj yeem siv tau - qib Estradiol Valerate API hmoov ncaj qha los ntawm tib neeg?
A: Cov tshuaj no - qibEstradiol Valerate hmoovyog cov khoom siv tshuaj thiab yuav tsum tsis txhob muab ncaj qha rau ntawm qhov ncauj, txhaj, lossis siv. Nws yuav tsum tau ua tiav rau hauv cov qauv tsim los ntawm cov kws tsim tshuaj ua ntej siv.
Q2: Puas yog qhov purity ruaj khov ntawm cov khoom siv, thiab puas tswj tau cov impurities?
A: Tsim los siv cov cuab yeej ua kom paub tab, HPLC purity tseem nyob ruaj khov ntawm Ntau dua lossis sib npaug li 99.0%, thaum muaj feem xyuam rau cov khoom siv thiab cov hlau hnyav yog tswj nruj heev.
Q3: Dab tsi yog qhov txawv ntawm Estradiol Valerate thiab estradiol li niaj zaus?
A: Estradiol Valerate yog ib qho tshuaj uas muaj zog lipophilicity, ruaj khov dua hauv vivo tso tawm cov yam ntxwv, thiab lub sijhawm ua haujlwm nruab nrab.
Q4: Cov ntaub ntawv npaum li cas yog cov khoom nyoos no haum rau?
A: Nws yog qhov tsim nyog rau cov ntsiav tshuaj ntawm qhov ncauj, ntev -cov roj ua haujlwm- raws li kev txhaj tshuaj, kev txhawb nqa - tso tawm cov tshuaj, thiab lwm yam kev tsim tshuaj estrogen.
Hoobkas
Daim ntawv pov thawj
Shipping & Packing
Tiv tauj peb rau kev yuav khoom|Kev Pabcuam Tau Zoo & Kev Ua Haujlwm Tom Qab -Kev Pabcuam Muag
Siab -purityEstradiol Valerate hmoovrau preclinical R&D thiab ntev -kev tsim cov tshuaj estrogen formulation yog muaj nyob thoob ntiaj teb rau HRT cov kev tshawb fawb, kev tsim tshuaj formulation, thiab endocrine kev tshawb fawb, muab ruaj khov, raws li, thiab traceable raw cov ntaub ntawv daws rau lub ntiaj teb no kws tshuaj tuam txhab uas muag, cov chaw tshawb fawb, thiab cov kws lag luam tshuaj.
Kev sim ua piv txwv, kev yuav khoom ntau, thiab cov khoom siv kho kom haum yog muaj, nrog rau kev xa khoom zoo thiab kev ua tiav tom qab - kev txhawb nqa kev muag khoom.
Rau cov ntaub ntawv soj ntsuam zoo, cov qauv hais, lossis cov lus qhia ntxaws ntxaws, thov hu rau peb:
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Cim npe nrov: estradiol valerate hmoov, Tuam Tshoj estradiol valerate hmoov manufacturers, lwm tus neeg, Hoobkas
