Trimethoprim API CAS 738-70-5|Ntau dua lossis sib npaug rau 98% Antibacterial Synergist Chaw Tsim Tshuaj Tuam Tshoj

Ntsiab Muag Khoom

✓ Diaminopyrimidine Antibacterial - Xaiv cov kab mob DHFR Inhibitor

✓ Kub-Standard Sulfonamide Synergist - Sequential Folate Blockade (Bactericidal)

✓ Co-Trimoxazole Partner - SMX:TMP 5:1, WHO Essential Medicine

✓ Broad Gram-Positive & Gram-Negative Spectrum - E. coli, Pasteurella, Streptococcus, Staph

✓ Kev nqus qhov ncauj zoo heev & Kev faib tawm cov ntaub so ntswg - Prostate, Ua pa, UTI

✓ Tib neeg & Veterinary API - UTI, Respiratory, Prostatitis, PJP Prophylaxis

Trimethoprim Powder yog dab tsi?

Trimethoprim hmoov(TMP) yog ib qho hluavtaws diaminopyrimidine antibacterial, tshuaj 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine. Nws yog qhov zoo tshaj plaws hu ua diaminopyrimidine tivthaiv ntawm co-trimoxazole - taag 5: 1 ua ke nrog sulfamethoxazole (SMX), teev nyob rau hauv WHO Model List of Essential Medicines - thiab kuj tau ua ke nrog sulfadiazine (co-trimazine) thiab sulfadoxine (co-trimoxine).

Nws yog siv ib leeg rau kev tsis sib haum xeeb UTI thiab prostatitis, thiab ua ke nrog SMX rau cov kab mob ua pa, cov neeg taug kev raws plab, thiab kev tiv thaiv kab mob / kev kho mob.Pneumocystis jiroveciipneumonia (PJP), toxoplasmosis thiab nocardiosis. Hauv kev xyaum kho tsiaj nws yog tsim nrog sulfonamides rau kev ua pa, GI thiab cov kab mob urinary nyob rau hauv nyuj, yaj, npua, nqaij qaib, dev thiab miv los ntawm cov kab mob raug mob. Ib leeg bacteriostatic; nws tus nqi yog nyob rau hauv kev xaiv inhibition ntawm cov kab mob DHFR (~ 50,000-fold affinity tshaj mammalian DHFR). Zoo nqus tau qhov ncauj, cov ntaub so ntswg zoo (xws li prostate), ib nrab -lub neej ~ 8-12 teev. Cov koob tshuaj ntau / ntev yuav ua rau tsis muaj folate (tswj tau nrog folic acid); co-trimoxazole cov teebmeem tshwm sim loj tshaj plaws yog sulfonamide ntsig txog.

Trimethoprim Powder ua haujlwm li cas?

Trimethoprim Powder xaiv thiab thim rov qab inhibits cov kab mob dihydrofolate reductase (DHFR), thaiv kev hloov pauv ntawm dihydrofolic acid (DHF) rau tetrahydrofolic acid (THF) - active folate coenzyme rau purine, thymidine thiab amino acid synthesis. VimTrimethoprim hmoovkhi cov kab mob DHFR deb dua nruj dua li cov tsiaj nyeg DHFR, nws depletes THF xaiv hauv cov kab mob, ntes DNA replication. Ib leeg bacteriostatic.

Nws lub ntsiab lus txhais yog kev sib koom ua ke nrog sulfonamides: sulfonamides inhibit DHPS ntawm cov kauj ruam ua ntej folate, thaum TMP thaiv DHFR tom ntej - ib qho kev thaiv kab mob uas hloov cov kab mob bacteriostasis rau cov kab mob bactericidal, nthuav dav spectrum thiab slows resistance. Qhov zoo tshaj plaws cov ntaub so ntswg piv ~ 1:20 (TMP: sulfonamide), ua tiav nrog 1: 5 qhov ncauj tsau koob. Active tiv thaiv Gram-zoo (Staphylococcus, Streptococcus, Listeria) thiab Gram -negative (E. coli, Klebsiella, Proteus, Salmonella, Pasteurella) cov kab mob, ntxiv rauP. jiroveciithiabT. gondiinrog SMX. Lub raum excretion; kev hloov koob tshuaj hauv lub raum tsis zoo.

Dab tsi yog Daim Ntawv Thov ntawm Trimethoprim Powder?

Kab Mob Kab Mob Hauv Kab Mob: Uncomplicated UTI tshwm sim los ntawm raugE. colithiab lwm yam Gram-negative uropathogens (siv ib leeg lossis ua co-trimoxazole).
Cov kab mob ua pa: mob ua rau mob ntsws ntev, sinusitis thiab mob ntsws, feem ntau yog co-trimoxazole lossis potentiated sulfonamide ua ke.
Pneumocystis jirovecii Pneumonia (PJP): Prophylaxis thiab kev kho mob hauv cov neeg mob immunocompromised - kub- qauv qhia rau co-trimoxazole.
Veterinary Infections: Formulated nrog sulfonamides rau kab mob bovine ua pa (Pasteurella, Mannheimia), swine pleuropneumonia (Actinobacillus, Streptococcus suis), nqaij qaib colibacillosis thiab pasteurellosis, thiab canine/feline UTI, kab mob ntawm daim tawv nqaij thiab ua pa.
Cov kab mob hauv plab: Cov neeg taug kev raws plab (ETEC), shigellosis thiab lwm yam kab mob uas muaj kab mob enteritides.

Qhov txawv ntawm Trimethoprim thiab Sulfamethoxazole yog dab tsi?

Feature	Trimethoprim	Sulfamethoxazole
CAS	738-70-5	723-46-6
Chav kawm	Diaminopyrimidine	Sulfonamide
Lub hom phiaj Enzyme	DHFR (dihydrofolate reductase)	DHPS (dihydropteroate synthase)
Txoj Kev Kauj Ruam	DHF → THF	PAB → DHF
Ib leeg	Bacteriostatic	Bacteriostatic
Ua ke	Sequential blockade → bactericidal	Sequential blockade → bactericidal
Ib nrab -Lub neej	8-12 hnub	10-12 hnub
Selective Toxicity	High (cov kab mob DHFR)	High (cov kab mob ua kom cov folate)
Cov teebmeem tseem ceeb	Folate deficiency (cov koob tshuaj ntau)	Hypersensitivity / SJS, crystalluria

Trimethoprim piv nrog lwm yam Diaminopyrimidines li cas?

Feature	Trimethoprim	Ormetoprim	Diaveridine	Pyrimethamine
CAS	738-70-5	6981-18-6	5355-16-8	58-14-0
Kev siv thawj zaug	Tib neeg + veterinary broad	Veterinary (poultry)	Veterinary (poultry coccidia)	Tib neeg (toxoplasma, malaria)
Tus khub	Sulfamethoxazole	Sulfadimethoxine	Sulfadimidine	Sulfadiazine
Bacterial DHFR Selectivity	Siab	Siab	Nruab nrab	qis (antiprotozoal)
Ib nrab -Lub neej	8-12 hnub	~ 6 hnu	Luv luv	~ 4 hnub (ntev)
PJP Activity	Yog (nrog SMX)	Tsis muaj	Tsis muaj	Yog (nrog SD)
Kev siv Veterinary	Txhua hom	Nqaij qaib	Nqaij qaib / coccidia	Dog/cat toxoplasma

Trimethoprim Powder Ua li cas?

Trimethoprim Powder yog tsim los ntawm cov tshuaj synthesis uas muaj condensation ntawm 3,4,5-trimethoxybenzaldehyde nrog ib tug guanidine / pyrimidine intermediate, ua raws li los ntawm kev txo thiab purification.

Raw Khoom QC → 3,4,5-Trimethoxybenzaldehyde Kev Npaj → Condensation nrog 2,4-Diaminopyrimidine Intermediate → Txo / Cyclization → Crude Trimethoprim → Purification (Recrystallization los ntawm Ethanol / Dej) → Qhuav → Qing → milling

HDM BIO tswj qhov tseem ceeb condensation, txo qis thiab crystallization tsis muaj peev xwm tswj tau qhov zoo ib yam purity thiab batch zoo.

Cov Lus Qhia Zoo

Cov khoom kuaj	Txuj	Yam tshwm sim
Qhov tshwm sim	Dawb rau tawm -dawb hmoov	Zoo ib yam
Kev ntsuam xyuas (HPLC)	Ntau dua lossis sib npaug li 98.0%	99.0%
Tus Kheej (IR)	Ua raws li tus qauv siv	Kev lees paub
Melting Point	199-203 degree	201 degree
Poob rau ziab	Tsawg dua lossis sib npaug li 0.5%	0.2%
Residue ntawm Ignition	Tsawg dua lossis sib npaug li 0.1%	Ua raws
Hnyav Hlau	Tsawg dua los yog sib npaug li 10 ppm	Ua raws
Arsenic	Tsawg dua lossis sib npaug li 2 ppm	Ua raws
Yam khoom muaj feem	Nyob rau hauv specification	Hla
Residual Solvents	Nyob rau hauv specification	Hla

Cov Kev Tswj Xyuas Zoo Ua Li Cas rau Trimethoprim Powder?

Txhua pawg tau dhau los ua ntau yam -txoj kev tswj kom zoo ua ntej tso tawm kom paub tseeb tias tus kheej, purity thiab lub cev muaj zog.

Raw Khoom QC → Hauv -Kev Tswj Xyuas Txheej Txheem → HPLC Assay → IR Identity Verification → Melting Point Determination → Related Substances (HPLC) → Loss on Drying → Heavy Metals → Arsenic → Residue on Ignition → Residual Solvents → Residual Batch

Cov kev ntsuas tseem ceeb suav nrog kev txheeb xyuas los ntawm infrared (IR) spectroscopy, HPLC active cov ntsiab lus kev soj ntsuam, kev txiav txim siab ntawm melting point, ntsig txog tshuaj ntsuam xyuas, poob ntawm ziab, hnyav hlau thiab arsenic txwv, residue ntawm ignition thiab residual kuab tshuaj ntsuam xyuas. Txhua pawg lag luam tau txais kev txhawb nqa los ntawm ib pawg -COA tshwj xeeb thiab cov ntaub ntawv txheeb xyuas cuam tshuam rau QC tuaj thiab cov khoom tsim nyog.

Dab tsi cuam tshuam rau Trimethoprim Powder Bulk Nqe?

Trimethoprim Powder bulk pricing yog tsav los ntawm ntau yam tseem ceeb:

Synthesis Cov Nqi: Ntau-cov tshuaj synthesis suav nrog trimethoxybenzaldehyde condensation thiab pyrimidine cyclization ncaj qha cuam tshuam rau kev tsim khoom.
Purity & Qib: Siab purity (Ntau dua los yog sib npaug rau 99%) thiab cov kws kho mob -qib (USP/EP) batches hais kom them nqi tshaj tus qauv qib.
Kev Tswj Xyuas Kev Ua Tau Zoo & Daim Ntawv Pov Thawj: GMP- qauv API batch nrog DMF/CEP thiab COA zoo ib yam xav tau tus nqi siab dua.
Order Volume: Loj -scale cov ntawv cog lus tshuaj tau txais steeper rau ib -kilogram luv nqi tshaj me me -batch xaj.
Logistics & Geography: Txias cia / lub teeb - tiv thaiv kev ntim khoom thiab kev lis kev cai ua raws ntxiv rau tus nqi tsaws.

Hu rau HDM BIO rau cov lus hais tam sim no thiab ntim-raws li tus nqi.

Vim li cas thiaj xaiv HDM BIO ua koj tus neeg muag khoom Trimethoprim hmoov?

High-purity (Ntau dua lossis sib npaug rau 98% / raug 99%) diaminopyrimidine DHFR inhibitor nrog cov pov thawj sulfonamide synergy
Kub-tus qauv co-trimoxazole tus khub - 5:1 SMX:TMP, WHO Essential Medicine
Dav -kev ua spectrum nrog kev nqus ntawm qhov ncauj thiab cov ntaub so ntswg faib (xws li prostate)
GMP -ua raws li kev tsim khoom, ISO & HACCP tau ntawv pov thawj zoo
Tag nrho batch traceability thiab ua tiav cov ntaub ntawv (COA, MSDS, HPLC)
Kev xa khoom yooj yim: kilogram qauv mus rau tuj - qib xaj ntau
Kev xa tawm thoob ntiaj teb mus rau 70+ lub teb chaws nrog kev txhawb nqa tag nrho

Ntim Ntim, Shipping & Cia

Ntim: Cov hnab ntawv rau cov qauv thiab cov dej noo-cov ntaub ntawv pov thawj fiber ntau rau kev txiav txim ntau.
Custom Packaging: OEM labeling muaj.
Cov ntaub ntawv xa khoom: COA, MSDS / SDS, daim ntawv them nqi lag luam, cov ntawv ntim khoom thiab cov ntaub ntawv kev lis kev cai muaj raws li kev txiav txim siab.
Cia: Khaws nruj nreem kaw rau hauv qhov chaw txias, qhuav, lub teeb - tiv thaiv ib puag ncig. Lub neej txee: 24 lub hlis.
Kev tuav: Rau cov khoom siv raw khoom siv xwb; tsis yog rau kev tswj xyuas kev kho mob ncaj qha.

Cov lus nug nquag nug txog Trimethoprim Powder

Q1: Trimethoprim Powder yog dab tsi?

A: Ib qho hluavtaws diaminopyrimidine antibacterial (TMP) uas xaiv inhibits cov kab mob dihydrofolate reductase (DHFR), zoo tshaj plaws hu ua tus khub ntawm sulfamethoxazole hauv co-trimoxazole.

Q2: Tus lej CAS yog dab tsi?

A: 738-70-5.

Q3: Trimethoprim ua haujlwm li cas?

A: Nws reversibly inhibits kab mob DHFR, thaiv kev hloov ntawm DHF rau THF. Nrog sulfonamides (uas inhibit DHPS ntawm cov kauj ruam ua ntej), nws tsim ib qho kev sib txuas ntawm folate txoj kev thaiv nrog cov kab mob sib koom ua ke.

Q4: Co-trimoxazole yog dab tsi?

A: Kev sib xyaw ua ke ntawm trimethoprim thiab sulfamethoxazole hauv qhov sib piv 1: 5 (piv txwv li, 80 mg / 400 mg lossis 160 mg / 800 mg), uas yog cov kab mob bactericidal thiab teev raws li WHO Cov Tshuaj Tseem Ceeb.

Q5: Dab tsi yog trimethoprim siv rau?

A: Cov kab mob urinary, prostatitis, kab mob ua pa, cov neeg taug kev raws plab, thiab - as co-trimoxazole - PJP prophylaxis/kev kho mob, toxoplasmosis thiab nocardiosis. Hauv Veterinary: potentiated sulfonamide formulations rau ua pa / GI / UTI hauv cov tsiaj nyeg thiab tsiaj.

Q6: Cov ntaub ntawv twg yog muab rau txhua pawg?

A: Batch- tshwj xeeb COA, HPLC daim ntawv tshaj tawm, IR cov ntaub ntawv tus kheej, cov ntaub ntawv melting point, MSDS / SDS thiab cov ntaub ntawv xa tawm cuam tshuam.

Q7: Dab tsi purity koj muab?

A: Standard Ntau dua lossis sib npaug rau 98% HPLC; raug batch tshwm sim 99%. USP/EP-qib muaj nyob rau ntawm kev thov.

Q8: Kuv tuaj yeem yuav nws li cas los ntawm Tuam Tshoj?

A: HDM BIO muab cov khoom siv Trimethoprim Powder nrog batch COA thiab kev txhawb nqa thoob ntiaj teb.

Q9: Trimethoprim Powder nqi ntau npaum li cas?

A: Tus nqi ntau yog nyob ntawm cov nqi sib txuas, purity / qib, kev tswj hwm, kev txiav txim ntim thiab kev xa khoom. Hu rau HDM BIO rau cov lus hais tam sim no.

Q10: Puas muaj kev txhawj xeeb txog kev nyab xeeb?

A: Trimethoprim feem ntau zam tau zoo, tab sis cov koob tshuaj siab lossis ntev ntev yuav ua rau cov folate tsis muaj peev xwm (megaloblastic anemia, leukopenia, thrombocytopenia), tswj tau nrog folinic acid. Cov teebmeem loj tshaj plaws hauv co-trimoxazole yog tshwm sim los ntawm sulfonamide tivthaiv. Kev kho koob tshuaj yuav tsum tau nyob rau hauv lub raum tsis ua hauj lwm. Tsis yog rau kev tswj xyuas kev kho mob ncaj qha.