Myelin Oligodendrocyte Glycoprotein 35-55

MOG 35-55 Peptide GMP Tus neeg muag khoom hauv Suav teb|High-Purity Myelin Oligodendrocyte Glycoprotein 35-55 API rau EAE Qauv Kev Tshawb Fawb & Cov Khoom Muag Khoom Muag

Cov khoom tseem ceeb tseem ceeb

• Siab -purity MOG 35–55 peptide
• Uniform batch zoo rau kev ntsuam xyuas neuroimmunology txhim khu kev qha
• GMP Fmoc SPPS hluavtaws tshuab
• Factory direct supply, mg to kg bulk orders with sis tw

MOG 35-55 peptide (Myelin Oligodendrocyte Glycoprotein 3555)yog ib qho 21-amino-acid hluavtaws linear peptide muab tau los ntawm thaj chaw tiv thaiv kab mob ntxiv ntawm nas myelin oligodendrocyte glycoprotein (MOG).

Nws yog dav siv raws li tus qauv antigen rau inducing kev sim autoimmune encephalomyelitis (EAE), uas yog feem ntau pom zoo tsiaj qauv ntawm ntau yam sclerosis.

Cov khoom no yog muab los ua dawb rau tawm-cov hmoov dawb ua raws li GMP-ua raws Fmoc khoom-theem peptide synthesis (SPPS), ua raws li ntau- cov kauj ruam npaj HPLC purification thiab desalting.

Mass spectrometry lees paub qhov tseeb qhov hnyav molecular thiab siab ua raws li kev ncaj ncees, tsis muaj cov protein ntau txawv teb chaws lossis cov kab mob pyrogen.

Cov peptide yog dav siv hauv:

Kev tshawb nrhiav neuroimmunology mechanism

Tus kab mob demyelination modeling

autoimmune teb txoj kev tshawb fawb

preclinical tshuaj ntsuam xyuas thiab kev soj ntsuam kev ua tau zoo

• Kev tsim tawm siab hauv autoimmune encephalomyelitis qauv induction
• Tsawg endotoxin txo qis tsis yog{0}}kev cuam tshuam tshwj xeeb
• Muaj zog antigen tshwj xeeb rau qhov tseeb MOG- lub hom phiaj tiv thaiv kab mob
• Solubility zoo heev rau kev npaj sai sai
• Tag Nrho COA, HPLC, thiab MS cov ntaub ntawv ua kom muaj kev sim traceability

• Induction ntawm kev sim autoimmune encephalomyelitis (EAE) qauv
• Ua kom MOG- tshwj xeeb CD4+ T-cov lus teb ntawm tes
• Kev txhawb nqa ntawm inflammatory cytokines xws li IL-17 thiab IFN-
• Generation of anti-MOG antibody response in vivo
• Preclinical ntsuam xyuas ntawm neuroprotective thiab immunomodulatory tebchaw

• GMP-tswj Fmoc khoom-theem peptide synthesis kom paub meej qhov tseeb
• Multi-pab HPLC purification tshem tawm cov truncated thiab tshem tawm impurities
• nruj cleanroom manufacturing ib puag ncig nyob rau hauv Suav teb
• Tag nrho batch traceability los ntawm raw khoom mus rau cov khoom tiav
• ruaj khov scalable ntau lawm los ntawm gram mus rau kilogram kom muaj nuj nqis

• Hauv vivo, MOG 35-55 yog ua tiav los ntawm cov tshuaj antigen- nthuav tawm cov hlwb thiab nthuav tawm los ntawm MHC-II molecules, ua rau ua kom muaj MOG-specific CD4+ T cells. Activated T hlwb tsiv mus rau hauv nruab nrab lub paj hlwb, ua rau inflammatory infiltration thiab demyelination, yog li ua raws li ntau yam sclerosis pathology.
• Hauv vitro, peptide txhawb nqa lymphocyte proliferation thiab cytokine tso tawm, ua rau lub cev tiv thaiv kab mob thiab kev tshawb fawb pharmacological inhibition.

• GMP-ua raws li kev tsim cov chav huv huv nrog kev tswj kom muaj kab mob
• Tag nrho traceability los ntawm raw amino acids mus rau qhov kawg peptide API
• Multi-layer QC kuaj: HPLC, MS, sequence validation, endotoxin testing
• Ntev - kev tshawb fawb txog kev ruaj ntseg ntawm -20℃cia tej yam kev mob
• Kev xaiv thib peb -ib tog pov thawj rau kev tshawb fawb txog kev siv

Cim npe nrov: Tuam Tshoj myelin oligodendrocyte glycoprotein 35-55 manufacturers, lwm tus neeg, Hoobkas