Arg Gly Asp Peptide

Siab -Purity RGD Peptide Chaw tsim khoom hauv Suav teb|GMP Qib Arg-Gly-Asp Integrin Binding Peptide rau Cell Adhesion & Tumor Research

Cov khoom tseem ceeb tseem ceeb

• Siab -kev sib raug zoo integrin binding rau kev tshawb fawb ntawm cell adhesion txhim khu kev qha
• Dual muaj nuj nqi los txhawb lossis thaiv cell -ECM kev sib cuam tshuam
• Ua kom FAK/MAPK txoj hauv kev rau kev tsiv teb tsaws ntawm tes thiab kev tshawb fawb txog kev loj hlob
• Cov dej solubility zoo heev rau hauv vitro thiab hauv vivo kev sim
• Muaj feem xyuam rau cov qog hom phiaj, angiogenesis thiab kev tshawb fawb qhov txhab kho
• Tsawg impurities thiab zoo ib yam bioactivity thoob batch

RGD Peptide (Arg-Gly-Asp Peptide)yog ib qho khoom sib xyaw tripeptide ua ke ntawm Arg-Gly-Asp, CAS No. 99896-85-2, molecular mis C12H22N6O6, thiab molecular hnyav 346.34 Da. Nws sawv cev rau qhov kev txuag ntawm cov cell adhesion kev paub zoo heev uas muaj nyob rau hauv extracellular matrix proteins xws li fibronectin, vitronectin, thiab osteopontin.

Nws yog ib qho tseem ceeb ntawm cov cuab yeej molecular hauv cell biology, biomaterials science, thiab tshuaj kho mob qog noj ntshav rau kev kawm integrin - mediated adhesion thiab signaling pathways.

Cov khoom no zoo nkaus li dawb rau tawm - cov hmoov dawb. Nws yog tsim los siv optimized Fmoc solid-theem peptide synthesis (SPPS), ua raws li ntau-pab HPLC purification, desalting, thiab sterile lyophilization. Tag nrho cov txheej txheem ua raws li GMP cov qauv nruj, kom ntseeg tau tias tsawg kawg ntawm cov peptides truncated, oxidation byproducts, thiab stereoisomer impurities.

RGD Peptide (Arg-Gly-Asp Peptide)yog dav siv nyob rau hauv cell adhesion assays, integrin signaling kev tshawb fawb, qog invasion qauv, angiogenesis kev tshawb fawb, biomaterial nto hloov kho, tshuaj xa systems, thiab cell kab lis kev cai txheej daim ntaub ntawv.

1. High -kev paub tshwj xeeb integrin nrog kev ruaj khov kev ua haujlwm

RGD ib ntus xaiv khi ntau hom integrin subtypes (v 3, v 5, 5 1, IIb 3), kom ntseeg tau tias qis qis - lub hom phiaj kev sib cuam tshuam thiab cov txiaj ntsig kev sim ua tau zoo heev.

2. Dual- qauv ua haujlwm: adhesion nce qib thiab kev sib tw inhibition

Thaum tsis tshua muaj immobilized concentrations, RGD txhawb nqa cell adhesion; Nyob rau hauv daim ntawv soluble, nws muaj kev sib tw inhibits ECM binding, ua rau ob txoj kev sim sib txawv nrog ib qho molecule.

3. Ua kom muaj kev taw qhia tseem ceeb rau kev kawm tshuab

RGD-integrin binding ua rau FAK, MAPK, thiab PI3K/AKT signaling cascades, tswj cell migration, proliferation, survival, thiab cytoskeletal remodeling.

4. Zoo heev aqueous solubility rau saj zawg zog sim tsim

Soluble tag nrho hauv aqueous buffers yam tsis muaj cov kuab tshuaj organic, sib xws nrog cov kab lis kev cai ntawm tes, biomaterials, thiab hauv vivo kev sim teeb tsa.

5. Tsawg impurity thiab endotoxin profile kom huv si tom qab sim

Kev ua kom huv huv nruj tshem tawm cov truncated thiab oxidized peptides, txo qhov mob thiab cov lus teb tsis tshwj xeeb ntawm tes.

6. Ua kom tiav cov ntaub ntawv pov thawj rau kev tshawb fawb thiab luam tawm siv

Txhua batch suav nrog COA, HPLC chromatograms, MS cov ntaub ntawv, kev txheeb xyuas kab ke, thiab 2-xyoo kev ruaj ntseg cov ntaub ntawv.

• Cell adhesion, migration, invasion, thiab proliferation assay
• Cov qog nqaij hlav metastasis thiab cov qauv angiogenesis
• Biomaterial nto functionalization thiab hydrogel engineering
• Integrin-FAK qhia txoj hauv kev kawm
• Cov ntaub so ntswg engineering thiab kev tshawb nrhiav qhov txhab kho
• Targeted drug delivery system kev loj hlob
• Zoo tswj peptide hauv integrin ligand kuaj

RGD peptide khi integrins los ntawm hlau - ion- nyob ntawm qhov chaw adhesion (MIDAS), ua kom muaj kev taw qhia ntawm tes taw qhia:

Integrin paub mechanism
Aspartic acid ua haujlwm nrog Mg²⁺/Mn²⁺ hauv -subunit, thaum arginine tsim ionic kev sib cuam tshuam nrog -subunit.

Cell adhesion signaling activation
Ua rau integrin clustering → FAK phosphorylation → Src/ERK txoj kev ua kom → cytoskeletal remodeling.

Kev sib tw inhibition mechanism
Soluble RGD blocks ECM ligands xws li fibronectin, inhibiting adhesion, tsiv teb tsaws, thiab ntxeem tau.

qog aiming mechanism
Kev qhia siab ntawm v 3 integrins hauv qog vasculature ua rau muaj kev xaiv ntau ntawm RGD-raws li kev sojntsuam lossis cov neeg nqa tshuaj.

• GMP- tau lees paub qhov chaw tsim khoom hauv chav huv
• nruj raw khoom tsim nyog thiab cov neeg muag khoom audit system
• Tag nrho traceability los ntawm synthesis mus rau cov khoom kawg
• 2-xyoo stability validation ntawm -20 degree
• Thib peb -kev tshuaj ntsuam xyuas tog neeg muaj nyob rau ntawm kev thov

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