Linaclotide Acetate Powder CAS 851199-60-5|High Purity GC-C Agonist Peptide Supplier Tuam Tshoj

Core Muag Cov Ntsiab Lus

✅ Ntau dua lossis sib npaug li 98% HPLC Purity Research-Grade Peptide Khoom

✅ LC-MS Full Cyclic Octapeptide Sequence & Disulfide Bond Verification

✅ Batch-Specific COA, HPLC & MS Test Reports Muaj

✅ Optimized Fmoc SPPS Cyclization Workflow, In-house Independent QC Laboratory

✅ Cov ntaub ntawv xa tawm thoob ntiaj teb & hla ciam teb Cold-chain Logistics Support

✅ Custom Peptide Purification & Salt-form Adjustment Service

Linaclotide Acetate Powder yog dab tsi?

Linaclotide Acetate hmoovyog ib qho hluavtaws 14-amino-acid cyclic peptide acetate ntsev, stabilized los ntawm peb intramolecular disulfide daim ntawv cog lus, ua lub zog guanylate cyclase-C (GC-C) receptor agonistPMC. Nws ua rau intracellular cGMP nce siab nyob rau hauv plab hnyuv epithelial hlwb, dav siv rau kev tshawb fawb ntawm plab hnyuv physiology, cem quav-txog kev tshawb fawb mechanism, thiab chim siab plob tsis so tswj syndrome ua ntej soj ntsuam kev loj hlob PMC.

Tsim los ntawm optimized Fmoc solid-phase peptide synthesis, regioselective oxidative folding thiab multi-theem gradient HPLC ntsev-hloov purification, pebLinaclotide Acetate hmoovtswj kom raug triple disulfide-bond connectivity, compact bioactive conformation thiab zoo ib yam batch-to-batch biochemical kev ua tau zoo. HDM BIO ua haujlwm rau lub ntiaj teb biotech labs thiab cov kws tshuaj R & D pab pawg nrog cov khoom siv hauv chav kuaj thiab cov khoom loj loj. Cov khoom siv peptide no nruj me ntsis txwv rau kev tshawb fawb hauv chav kuaj tsuas yog siv thiab tsis tuaj yeem siv ncaj qha rau tib neeg kev tswj hwm kev kho mob.

Dab tsi yog Cov Txheej Txheem Zoo ntawm Linaclotide Acetate Powder?

Txhua pawg ntau lawm ntawm Linaclotide Acetate tau kuaj dual QC (HPLC + LC-MS) hauv HDM BIO analytical laboratory. Tshwj xeeb batch COA yuav raug xa tawm rau txhua qhov kev txiav txim yuav khoom ntau.

Yam khoom	Specification	Kev tshwm sim
Qhov tshwm sim	Dawb rau tawm -dawb hmoov	Zoo ib yam
Purity (HPLC)	Ntau dua lossis sib npaug li 98%	99.88%
MS Identity	Raws li tus qauv siv	Kev lees paub
Xaus	Cosmetic raw khoom xav tau	Dhau

Linaclotide Acetate vs Lwm GC-C Targeting Peptides

Rau cov neeg yuav khoom nrhiav cysteine-nplua nuj cyclic peptides rau kev tshawb fawb ntawm plab hnyuv, qhov kev sib piv no qhia meej txog qhov sib txawv ntawm cov khoom siv raw khoom:

Khoom	Target Mechanism	Tus yam ntxwv	Daim Ntawv Thov Kev Tshawb Fawb Tseem Ceeb	CAS Nr
Linaclotide Acetate	Muaj zog GC-C agonist, elevates plab hnyuv cGMP	14-mer peptide nrog peb daim ntawv cog lus disulfide	Constipation, IBS-C, kev tshawb fawb ntawm plab hnyuv	851199‑60‑5
Guanylin	Endogenous GC-C peptide agonist	15-amino-acid, ob daim ntawv cog lus disulfide	Txoj hnyuv plab physiology endogenous ligand piv kev soj ntsuam	147686‑86‑2
Uroguanylin	Endogenous GC-C receptor activator	16-amino-acid, ob daim ntawv cog lus disulfide	Kev tshawb fawb ntawm lub plab epithelial signaling pathway	147686‑85‑1

Tshooj lus no suav nrog cov lus tseem ceeb ntev: linaclotide vs guanylin, linaclotide acetate GC-C peptide, gastrointestinal cyclic peptide raw khoom.

Yuav ua li cas thiaj li yuav Linaclotide Acetate Powder los ntawm tus neeg muag khoom ntseeg tau?

Thaum muab khoomLinaclotide Acetate hmoovrau cov kws kho mob plab hnyuv thiab kab mob plab ua ntej kev soj ntsuam, pab pawg R & D thiab cov neeg yuav khoom thoob ntiaj teb peptide yuav tsum ntsuas tsib yam tseem ceeb kom tsis txhob muaj qhov txaus ntshai thiab txaus ntshai:

HPLC purity validation: Paub meej ntau dua los yog sib npaug rau 98% purity alongside tiav impurity chromatogram
LC-MS cov qauv kev pom zoo: Txheeb xyuas qhov ntev-ntev 14-mer ib ntus thiab kho triple disulfide-bond regioselective txuas
Batch-specific documentation: Guarantee txhua qhov kev txiav txim tuaj yeem sib phim nrog COA cov ntaub ntawv ywj pheej
Mature synthesis muaj peev xwm: Xaiv cov neeg muag khoom nrog cov pov thawj kev tsim peptides yuav tsum tau tswj triple disulfide oxidative folding
Kev pabcuam xa tawm thoob ntiaj teb: Txheeb xyuas cov neeg muag khoom tuaj yeem muab cov ntaub ntawv txhawb nqa tag nrho rau kev lis kev cai thoob ntiaj teb

HDM BIO muab kev tshawb fawb-qib Linaclotide Acetate nrog cov ntaub ntawv zoo, hloov tau yam tsawg kawg nkaus kom muaj nuj nqis thiab kev xa khoom thoob ntiaj teb rau kev sim me me thiab kev yuav khoom mus sij hawm ntev.

Linaclotide Acetate Powder Nqe & Daim Ntawv Qhia Ntau Yam 2026

Cov neeg yuav khoom tab tom nrhiav Linaclotide Acetate hmoov nqe, cov lus hais ntau peptide thiab cov nqe lus xa tuaj tuaj yeem xa mus rau cov ntaub ntawv tseem ceeb hauv qab no:

Yam tsawg kawg nkaus Order Quantity: Flexible MOQ, milligram & gram-theem sim kuaj muaj; kilogram bulk mov rau kev tshawb fawb txuas ntxiv
Qauv Nqi: Cov qauv sim rau kev soj ntsuam hauv chav kuaj; hu rau pab neeg muag khoom kom tau txais cov qauv hais
Bulk Kilogram Quotation: Tiered pricing txoj cai, kev txiav txim loj loj txaus siab rau cov nqi sib tw
Lub Sijhawm Lead Lub Sijhawm: Tus qauv coj lub sijhawm nyob ntawm qhov kev txiav txim ntim; kev muag khoom yuav lees paub lub sijhawm tsim khoom raws sijhawm raws li kev nug
Shipping Options: Cold-chain thauj mus los kom muaj ntau-disulfide peptide stability; peb muab cov ntawv xa nyiaj ua lag luam, cov ntawv ntim khoom thiab MSDS rau kev lis kev cai thoob ntiaj teb

Ntau yam tseem ceeb cuam tshuam rau qhov kawg hais: qib purity, customized kuaj yuav tsum tau, tshwj xeeb ntim specifications thiab txias-chain logistics nqi. Hu rau peb pab neeg muag khoom kom paub cov lus hais tawm tshiab.

Linaclotide Acetate Powder Procurement Guide for Global Buyers

Ua ntej kos npe rau daim ntawv cog lus yuav khoom rau ntau-disulfide-bond cyclic peptide raw cov ntaub ntawv, pab pawg neeg yuav khoom thoob ntiaj teb yuav tsum ua tiav cov kauj ruam pov thawj no txhawm rau txo cov kev pheej hmoo:

Kev pov thawj ntawm tus neeg muag khoom: Paub meej tias tus neeg muag khoom muaj kev ywj pheej peptide synthesis Rhiav thiab hauv tsev QC kuaj
Kev tshuaj xyuas cov ntaub ntawv: Thov ua ntej xa khoom xa tuaj batch COA, HPLC chromatogram thiab LC-MS daim ntawv qhia txog tus kheej
Kev pom zoo ntawm cov khoom: Tshawb xyuas peptide purity tus qauv, disulfide-daim ntawv cog lus daim ntawv qhia thiab kev cia khoom tshwj xeeb phim koj qhov kev sim tsim
MOQ & lub sij hawm ua: Paub meej tias muaj Tshuag, ntau lawm voj voog thiab kev txiav txim hloov txoj cai
Shipping cov ntaub ntawv: Paub meej tias tus neeg muag khoom tuaj yeem muab tag nrho cov ntaub ntawv xav tau rau kev xa tawm kev lis kev cai hauv koj cheeb tsam

Hais txog HDM BIO Linaclotide Acetate Manufacturing Capability

HDM BIO muaj ntau tshaj 10 xyoo ntawm kev paub tsom rau Fmoc solid-phase peptide synthesis thiab complex cysteine-nplua nuj multi-disulfide-bond peptide raw khoom tsim.

Dedicated SPPS ntau lawm kab optimized rau peptides yuav tsum regioselective triple oxidative folding
Lub chaw soj ntsuam ywj pheej nruab nrog HPLC, LC-MS, ntsuas dej noo thiab cov cuab yeej ntsuas hnyav
Peptide cov khoom xa tawm mus rau ntau dua 70 lub teb chaws, ua haujlwm hauv tsev kawm ntawv labs, biotech startups thiab kws tshuaj R & D lub koom haum
Muaj peev xwm tsim tau txhua xyoo ruaj khov rau kev tshawb fawb-qib peptide raw cov ntaub ntawv, txhawb kev koom tes ua haujlwm ntev
Pab pawg kws tshaj lij nrog kev paub nplua nuj hauv ntau-cysteine peptide xaiv oxidation, purification thiab ntsev-daim ntawv hloov dua siab tshiab

Peb lub chaw tsim khoom peptide ua haujlwm tshwj xeeb Fmoc SPPS cov kab ntau lawm nrog hauv tsev HPLC purification thiab LC-MS analytical peev xwm.

Cov Kev Sib Tw Dab Tsi Muaj nyob hauv Linaclotide Acetate Synthesis & Production?

Linaclotide Acetate yog 14-residue peptide uas muaj peb khub ntawm disulfide bonds; regioselective oxidative folding yog cov txheej txheem kev fwj dej sib cais tsim nyog peptide tuam ntxhab los ntawm cov neeg muag khoom qis PMC.

Cov teeb meem tseem ceeb ntawm kev tsim khoom muaj xws li:

Zam kev tsis raug disulfide-daim ntawv cog lus ua khub thiab tsim kom muaj ntau ntawm mis-folded isomer impurities
Tiv thaiv kev sib cuam tshuam ntawm cov dimerization thiab oligomer tsim thaum lub sij hawm oxidation ntau
Kev sib cais zoo ntawm cov txheej txheem zoo sib xws mis-folded variants ntawm ntau theem chromatography
Tswj peptide degradation thaum lub sij hawm folding thiab acetate ntsev-hloov txheej txheem
Reproducible batch-to-batch disulfide-bond configuration thiab biochemical kev ua

HDM BIO txais yuav orthogonal cysteine-protecting-group lub tswv yim, tswj regioselective oxidative folding raws tu qauv, multi-theem gradient HPLC purification thiab tag nrho-txheej txheem LC-MS xyuas rau txhua batch. Qhov no txo qis kev ua tsis zoo ntawm cov tshuaj disulfide impurities thiab lav zoo 14-mer peptide qauv thiab ruaj khov batch-to-batch zoo.

Linaclotide Acetate Powder ua haujlwm li cas hauv Kev Tshawb Fawb Kev Tshawb Fawb?

Raws li kev xaiv guanylate cyclase-C receptor agonist,Linaclotide Acetate hmoovkhi rau GC-C receptors qhia ntawm plab hnyuv epithelial hlwb, elevating intracellular cGMP concentration, txhawb dej thiab electrolyte secretion rau hauv plab hnyuv lumen, accelerating plab transit thiab modulating visceral mob signaling nyob rau hauv pre-kev kho mob qauvPMC.

Nws ua haujlwm raws li qhov kev sim ua pov thawj tseem ceeb rau kev tshawb fawb hauv plab hnyuv, cem quav ntev thiab IBS-C kev tshuaj xyuas, thiab GC-C tsom rau kev tshuaj ntsuam xyuas tshuaj-tus neeg sib tw. Tag nrho cov lus piav qhia txog kev siv tsuas yog siv rau hauv-vitro thiab pre-clinical tsiaj tshawb fawb scenarios.

Lanreotide Powder Ua li cas ntawm HDM BIO?

Linaclotide Acetate yuav tsum muaj kev tswj hwm nruj ntawm cov amino-acid coupling, regioselective multi-disulfide-bond folding thiab acetate ntsev hloov.

Nyeem cov lus qhia ntsig txog: Hloov kho Peptide API Manufacturing Guide|Fmoc SPPS Technology piav qhia

Ua kom tiav Linaclotide Acetate Manufacturing Workflow

Raw Material Inspection → 14-mer Peptide SPPS Stepwise Coupling → Resin Cleavage & Ntiaj Teb Deprotection → Regioselective Triple Disulfide-Bond Oxidative Folding → Multi-stage HPLC Purification → Acetate Salt-form Conversion → Issued Lyophilization Led → Full Q-C Ntim

QC Kev Tshawb Fawb Kev Ua Haujlwm

Cov Khoom Raw QC → In-process coupling & oxidative folding monitoring → HPLC Purity Test → Mass Spectrometry Identity Verification → Disulfide-bond peptide mapping → Moisture & Heavy-Metal Test → Residual Solvent Detection → Final Batch Release Approval

Cov txheej txheem tseem ceeb

Orthogonal cysteine tiv thaiv tswvyim los txhim kho disulfide-bond khub xaiv xaiv

Tswj oxidative folding kom txo cov mis-folded isomers thiab peptide dimer by-products

Multi-theem high-precision HPLC purification tshem tawm cov txheej txheem zoo sib xws folding variants

Full-structure LC-MS & peptide-mapping pov thawj lees paub qhov tseeb triple-disulfide txuas

Lub tshuab nqus tsev lyophilization thiab lub teeb-pov thawj ntim ntim khaws cia ntau-disulfide peptide ruaj khov thaum thauj thiab khaws cia qis

Dab tsi yog Daim Ntawv Thov Tseem Ceeb ntawm Linaclotide Acetate Powder?

Kev tshawb fawb ntawm plab hnyuv: GC-C receptor signaling, plab hnyuv-secretion thiab plab-motility mechanism thwmsim
Constipation & IBS-C kev tshawb fawb ua ntej: Visceral hypersensitivity thiab chim siab plob tsis so tswj tus qauv kev tshawb fawb
Novel gastrointestinal tshuaj ntsuam xyuas: Kev ntsuam xyuas ntawm GC-C-targeted peptide me-molecule tus neeg sib tw sib xyaw
Biomedical reagent npaj: Laboratory siv cov qauv thiab kev sim tswj reagents
Kev tshawb nrhiav peptide formulation: Oral luminal-acting peptide delivery system development

Vim li cas thiaj xaiv HDM BIO ua koj li Linaclotide Acetate Powder Supplier?

10+ xyoo ntawm kev ua haujlwm complex multi-disulfide-bond peptide raw-material manufacturing kev hauv Suav teb
Mature orthogonal-tiv thaiv regioselective folding txheej txheem rau triple-disulfide-bond 14-mer peptide
Nruam tag nrho cov qauv pov thawj thiab batch stability tswj rau txhua qhov ntau lawm
Ua kom tiav cov ntaub ntawv tshawb xyuas kev tsim khoom rau txhua pawg ntawm Linaclotide Acetate
Flexible mov: gram-level lab kuaj mus rau kilogram-theem bulk peptide xaj
Kev pabcuam xa tawm thoob ntiaj teb npog ntau dua 70 lub tebchaws thiab cheeb tsam
Cov kws tshaj lij pabcuam pabcuam pabcuam kev pabcuam kev noj qab haus huv-txoj kev peptide kev tshawb fawb

FAQs Txog Linaclotide Acetate Powder

Q: Qhov twg kuv tuaj yeem yuav Linaclotide Acetate hmoov los ntawm Tuam Tshoj?

A: HDM BIO yog Tuam Tshoj-based complex cyclic peptide muab kev pabcuam siabLinaclotide Acetate hmoovrau thoob ntiaj teb kws tshuaj R & D pab pawg thiab biotech laboratories. Peb muab cov qauv tshawb fawb me me thiab cov xaj loj loj, txhawb nqa los ntawm cov ntaub ntawv xa tawm tiav thiab xa khoom thoob ntiaj teb.

Q: Cov ntaub ntawv dab tsi yuav tsum muaj peev xwm muab tau Linaclotide Acetate?

A: Cov neeg muag khoom ntseeg siab tuaj yeem muab cov khoom tshwj xeeb COA, HPLC purity chromatogram, LC-MS daim ntawv qhia txog tus kheej, cov ntaub ntawv disulfide-daim ntawv cog lus, MSDS thiab ua tiav cov ntaub ntawv pov thawj kev tsim khoom rau kev soj ntsuam zoo thiab kev lis kev cai.

Q: Tus lej CAS ntawm Linaclotide Acetate yog dab tsi?

A: Tus lej CAS npe ntawm Linaclotide Acetate yog 851199-60-5.

Q: Dab tsi purity qib ntawm Linaclotide Acetate hmoov koj tuaj yeem muab tau?

A: Qib kev tshawb fawb qib siab dua lossis sib npaug li 98% HPLC purity. Ntau dua purity specifications tuaj yeem kho tau rau kev sim tshwj xeeb.

Q: Yuav ua li cas lyophilized Linaclotide Acetate hmoov khaws cia?

A: Khaws kaw ntawm -20 degree, tiv thaiv lub teeb thiab noo noo. Tsis txhob rov qab khov-thaw cycles kom tswj tau ntau-disulfide peptide kev ruaj ntseg.

Q: Kuv puas tuaj yeem tau txais Linaclotide Acetate kuaj ua ntej kev koom tes ntau?

A: Yog. Peb muab milligram rau gram-theem sim cov qauv txuas nrog ua tiav COA thiab cov ntaub ntawv xeem rau kev soj ntsuam kuaj.

Q: Dab tsi yog MOQ rau bulk Linaclotide Acetate hmoov?

A: MOQ yog hloov tau raws li qib purity thiab ntim khoom. Peb txhawb nqa cov kev tshawb fawb me me thiab cov xaj loj loj kom ua tau raws li qhov xav tau sib txawv.

Q: Dab tsi yog qhov amino-acid sequence ntawm Linaclotide?

A: Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH; Peb daim ntawv cog lus disulfide: Cys1-Cys6, Cys2-Cys10, Cys5-Cys13Wikipedia

Kev Tshawb Fawb Txog Kev Tshawb Fawb

Kev tshuaj xyuas los ntawm: HDM BIO Peptide Technical Team Expertise: Peptide synthesis Multi-cysteine & triple-disulfide-bond cyclic peptide manufacturing Analytical chemistry & HPLC/LC-MS peptide mapping test

Kho tshiab kawg: Lub Yim Hli 2026

Kev lees paub: Tag nrho cov ntsiab lus ntawm cov khoom lag luam yog muab rau kev tshawb fawb kev kawm thiab cov khoom siv raw khoom siv xwb. Tsis yog siv rau tib neeg kev kho mob, kev kuaj mob lossis kev kho mob.