Closantel Sodium CAS 61438-64-0|High Purity Veterinary Antiparasitic API Chaw Tsim Tshuaj & Cov Khoom Muag Tuam Tshoj

Ntsiab Muag Khoom

✓ Salicylanilide Anthelmintic - Mitochondrial Oxidative Phosphorylation Uncoupler

✓ Muaj txiaj ntsig zoo rau lub siab Fluke - Fasciola hepatica & F. gigantica (Cov Neeg Laus + Cov Tsis Txaus Siab)

✓ Active Tawm tsam Benzimidazole-Resistant Haemonchus contortus - 100% Kab txo qis

✓ Tseem muaj txiaj ntsig tiv thaiv Ivermectin -Resistant Nematodes - Resistance-Tshem Tawm

✓ Plasma Albumin-Bound - Kev Ua Haujlwm Ntev Ntev Tawm Tsam Ntshav- Pub cov kab mob

✓ Broad Trematode + Nematode + Arthropod Larvae Spectrum - Nyuj / Yaj / tshis / Camelids

Closantel Sodium Powder yog dab tsi?

Closantel Sodium hmoovyog sodium ntsev ntawm closantel, ib qho hluavtaws salicylanilide anthelmintic tshuaj muaj feem xyuam rau rafoxanide thiab oxyclozanide. Nws yog ib qho dav -spectrum antiparasitic tus neeg saib xyuas nrog kev ua haujlwm siab tawm tsam trematodes (mob siab), haematophagous gastrointestinal nematodes thiab larval theem ntawm qee cov arthropods hauv nyuj, yaj, tshis thiab South American camelids. Closantel feem ntau khi rau plasma albumin, uas ua rau cov tshuaj nyob rau hauv cov hlab ntsha thiab coj nws cov dej num feem ntau rau cov ntshav - pub cov cab.

Hauv kev xyaum kws kho tsiaj, closantel sodium yog lub hauv paus kev kho mob rau fascioliasis tshwm sim los ntawm Fasciola hepatica thiab Fasciola gigantica, nrog rau kev ua tau zoo tiv thaiv cov neeg laus flukes (97–100%) thiab cov theem tsis paub qab hau (6- txog 8- mob khaub thuas{9s, 9} . Nws kuj tseem muaj txiaj ntsig zoo rau cov ntshav- nqus cov kab mob hauv plab, tshwj xeeb yog Haemonchus contortus - suav nrog benzimidazole- cov kab mob resistant, tawm tsam uas closantel ntawm 5.0 mg / kg tau ua tiav 100% worm txo hauv kev sim tshuaj, thiab ivermectin resistant. Lwm yam kev ua no suav nrog cov kab mob ntsws (Dictyocaulus), eyeworms (Thelazia), warble fly larvae (Hypoderma), nasal bot larvae (Oestrus ovis), mites, ntshauv thiab zuam. Closantel yog muaj nyob rau hauv cov tshuaj txhaj tshuaj, ncuav-rau formulations thiab qhov ncauj drenches, feem ntau ua ke nrog ivermectin, abamectin los yog mebendazole rau nthuav spectrum. Tsis zoo li triclabendazole, closantel tsis xav tau kev ua kom lub siab metabolic. Nws muaj qhov nqaim kev nyab xeeb: kev noj ntau dhau tuaj yeem ua rau pom kev cuam tshuam, qhov muag tsis pom kev thiab cov tsos mob ntawm lub paj hlwb, thiab kev ua raws li daim ntawv lo ntau npaum li cas thiab lub sijhawm tshem tawm yog qhov tseem ceeb.

Closantel Sodium hmoov ua haujlwm li cas?

Closantel Sodium Powder exerts nws anthelmintic nyhuv feem ntau raws li ib tug uncoupler ntawm mitochondrial oxidative phosphorylation nyob rau hauv parasite hlwb. Raws li ib tug proton ionophore, nws cuam tshuam cov proton gradient hla lub puab mitochondrial membrane, uncoupling electron thauj los ntawm ATP synthesis. Qhov no inhibition ntawm ATP ntau lawm - lub xovtooj ntawm lub zog thawj txiaj txiaj - induces ib tug loj thiab irreversible kev hloov nyob rau hauv tus cab lub zog metabolism, thaum kawg ua rau parasite tuag.

VimClosantel Sodium hmoovyog lipophilic heev thiab khi ntau heev rau plasma albumin, nws ncig ntawm cov ntshav siab thiab tau xaiv los ntawm cov ntshav- pub cov kab mob xws li Fasciola flukes thiab Haemonchus nematodes. Ntxiv nrog rau oxidative phosphorylation uncoupling, closantel zoo nkaus li cuam tshuam ion thauj cov txheej txheem hla cov kab mob cab thiab tuaj yeem cuam tshuam chitinase enzymes tseem ceeb rau larval molting hauv arthropod parasites. Nws cov dej num tiv thaiv ob tus neeg laus thiab cov neeg laus tsis paub qab hau cov kab mob siab ua rau pom cov tshuaj tiv thaiv nyob rau hauv cov kua tsib thiab cov ntaub so ntswg biliary. Kev tiv thaiv- tawg profile ntawm closantel - kev ua tau zoo tiv thaiv benzimidazole-tiv taus thiab ivermectin- tiv taus Haemonchus contortus - stems los ntawm nws cov txheej txheem sib txawv ntawm kev ua, uas tsis sib tshooj nrog -}tubulin khi ntawm benzimid} los yog 10 chloride benzimate. ua kom cov macrocyclic lactones. Qhov no ua rau closantel yog ib qho cuab yeej tseem ceeb hauv kev tswj cov kab mob sib xyaw ua ke uas tiv thaiv rau lwm cov chav kawm anthelmintic tau tshwm sim. Nyob rau hauv tus tswv tsev, closantel yog absorbed tsis hloov, muaj cov ntaub so ntswg tsis pub dhau ntawm cov hlab ntsha, thiab maj mam tshem tawm, pab txhawb rau nws prophylactic kev ua si mus ntev tiv thaiv reinfection los ntawm cov ntshav - pub cab.

Dab tsi yog Daim Ntawv Thov ntawm Closantel Sodium Powder?

Mob Fluke (Fascioliasis): Kev kho thiab tswj cov kab mob Fasciola hepatica thiab F. gigantica hauv nyuj, yaj thiab tshis - siv tau rau cov neeg laus thiab tsis paub tab (6-8 lub lis piam) flukes.
Gastrointestinal Nematodes: Kev kho cov ntshav- nqus nematodes suav nrog Haemonchus contortus (xws li benzimidazole- thiab ivermectin- cov kab mob resistant), Bunostomum thiab lwm yam haematophagous strongyles.
Lungworms & Eyeworms: Activity tiv thaiv Dictyocaulus viviparus / filaria (lungworms) thiab Thelazia hom (eyeworms) hauv nyuj thiab yaj.
Arthropod Larvae: Kev tswj ntawm warble fly larvae (Hypoderma bovis / lineatum), nasal bot larvae (Oestrus ovis), mites, ntshauv thiab zuam kab mob.
Combination Formulations: API rau txhaj tshuaj thiab ncuav- ntawm cov khoom ua ke nrog ivermectin, abamectin los yog mebendazole rau dav -spectrum endectocide kev ua si hauv nyuj, yaj, tshis thiab camelids.

Qhov txawv ntawm Closantel Sodium thiab Triclabendazole yog dab tsi?

Feature	Closantel Sodium	Triclabendazole
CAS	61438-64-0	68786-66-3
Cov tshuaj	Salicylanilide	Benzimidazole (Flukicide)
Mechanism	Oxidative phosphorylation uncoupler	-tubulin khi
Kab mob siab Fluke Stages	Cov neeg laus + lig immatures (6-8 wk)	Txhua theem incl. thaum ntxov immatures (1 wk)
Kev ua ntawm Nematode	Yog (ntshav-siv)	Tsawg kawg
Arthropod Larvae	Yog lawm	Tsis muaj
Hepatic Activation yuav tsum tau	Tsis muaj	Yog lawm (sulfoxide/sulfone metabolites)
Plasma Protein Binding	Siab (albumin)	Nruab nrab
Kev tiv thaiv	Tawm tshiab	Dav dav hauv ntau thaj tsam
Hom Kev Cai	Txhaj / ncuav -on / qhov ncauj	Qhov ncauj nqhis dej

Closantel piv nrog lwm cov Flukicides li cas?

Feature	Closantel	Rafoxanide	Oxyclozanide	Nitroxynil
CAS	61438-64-0	22662-39-1	2277-92-1	1689-89-0
Chav kawm	Salicylanilide	Salicylanilide	Salicylanilide	Hloov phenol
Mechanism	Ox phos uncoupler	Ox phos uncoupler	Ox phos uncoupler	Ox phos uncoupler
Tus Neeg Laus Fluke	Zoo heev	Zoo heev	Zoo	Zoo heev
Tsis paub Fluke	Ntev (6-8 hnub)	Ntev (6-8 hnub)	Cov neeg laus nkaus xwb	Ntev (6-8 hnub)
Nematodes	Ntshav- nqus	Ntshav- nqus	Tsawg kawg	Ntshav- nqus
Arthropods	Yog lawm	Yog lawm	Tsis muaj	Tsis muaj
Kev tswj hwm	Txhaj tshuaj / ncuav -on/oral	Qhov ncauj	Qhov ncauj	Txhaj tshuaj

Closantel Sodium Powder Ua li cas?

Closantel Sodium Powder yog tsim los ntawm ntau yam -cov tshuaj synthesis uas cuam tshuam nrog amide daim ntawv cog lus ntawm kev hloov salicylic acid thiab aniline derivative, ua raws li iodination, cyanomethylation thiab sodium ntsev tsim.

Raw Khoom QC → 3,5-Diiodo-2-hydroxybenzoic Acid Preparation → Hloov Aniline Synthesis (5-chloro-4- [(4-chlorophenyl) (cyano) methyl]-2-methylaniline) → Amide Coupling → Iodination → Cyanomethylation tel chlorification Crion (Recrystallization) → Qhuav → Milling → Kawg QC → Ntim

HDM BIO tswj cov kev sib txuas tseem ceeb, iodination, cyanomethylation thiab ntsev tsim tsis muaj peev xwm tswj tau cov purity zoo ib yam thiab batch zoo.

Cov Lus Qhia Zoo

Cov khoom kuaj	Txuj	Yam tshwm sim
Qhov tshwm sim	Dawb rau tawm -dawb hmoov	Zoo ib yam
Kev ntsuam xyuas (HPLC)	Ntau dua lossis sib npaug li 98.0%	99.0%
Tus Kheej (IR)	Ua raws li tus qauv siv	Kev lees paub
Melting Point	>230℃(decomposition)	>230 degree
Poob rau ziab	Tsawg dua lossis sib npaug li 0.5%	0.2%
Residue ntawm Ignition	Tsawg dua lossis sib npaug li 0.2%	Ua raws
Hnyav Hlau	Tsawg dua los yog sib npaug li 10 ppm	Ua raws
Cov ntsiab lus iodine	Nyob rau hauv specification	Ua raws
Yam khoom muaj feem	Nyob rau hauv specification	Hla
Residual Solvents	Nyob rau hauv specification	Hla

Qhov Kev Tswj Xyuas Zoo Ua Li Cas rau Closantel Sodium Powder?

Txhua pawg tau dhau los ua ntau yam -txoj kev tswj kom zoo ua ntej tso tawm kom paub tseeb tias tus kheej, purity thiab lub cev muaj zog.

Raw Khoom QC → Hauv -Kev Tswj Txheej Txheem → HPLC Assay → IR Identity Verification → Melting Point Determination → Iodine Content Analysis → Related Substances (HPLC) → Loss on Drying → Heavy Metals → Residue on Ignition → Residual Solvents Relatch

Cov kev ntsuas tseem ceeb suav nrog kev txheeb xyuas los ntawm infrared (IR) spectroscopy, HPLC active cov ntsiab lus kev soj ntsuam, kev txiav txim siab ntawm melting point, iodine cov ntsiab lus tsom xam, muaj feem xyuam rau cov tshuaj, poob ntawm qhuav, hnyav hlau txwv, residue ntawm ignition thiab residual kuab tshuaj ntsuam xyuas. Txhua pawg lag luam tau txais kev txhawb nqa los ntawm ib pawg -COA tshwj xeeb thiab cov ntaub ntawv txheeb xyuas cuam tshuam rau QC tuaj thiab cov khoom tsim nyog.

Dab tsi cuam tshuam rau Closantel Sodium Powder Bulk Nqe?

Closantel Sodium Powder bulk pricing yog tsav los ntawm ntau yam tseem ceeb:

Synthesis Cov Nqi: Ntau- cov tshuaj synthesis suav nrog amide coupling, iodination thiab cyanomethylation, nrog iodine ua cov khoom siv kim heev, cuam tshuam ncaj qha rau cov nqi tsim khoom.
Purity & Qib: Siab purity (Ntau dua los yog sib npaug rau 99%) thiab cov kws kho mob - qib batches hais kom them nqi tshaj tus qauv veterinary qib.
Kev Tswj Xyuas Kev Ua Tau Zoo & Daim Ntawv Pov Thawj: GMP- qauv API batch nrog COA zoo ib yam thiab ua tiav cov ntaub ntawv xa tawm xav tau tus nqi siab dua.
Order Volume: Loj -scale veterinary pharmaceutical daim ntawv cog lus tau txais steeper ib -kilogram luv nqi tshaj me me -batch xaj.
Logistics & Geography: Lub teeb- tiv thaiv / txias cia ntim cov cai thiab kev lis kev cai ua raws ntxiv rau tus nqi tsaws.

Hu rau HDM BIO rau cov lus hais tam sim no thiab ntim-raws li tus nqi.

Vim li cas thiaj xaiv HDM BIO raws li koj tus Closantel Sodium Powder Supplier?

High-purity (Ntau dua los yog sib npaug rau 98% / raug 99%) salicylanilide anthelmintic nrog pov thawj daim siab fluke thiab resistant-nematode efficiency
Resistance-breaking profile - nquag tawm tsam benzimidazole- thiab ivermectin-resistant Haemonchus contortus
Broad trematode + nematode + arthropod larvae spectrum rau nyuj, yaj, tshis thiab camelids
GMP -ua raws li kev tsim khoom, ISO & HACCP tau ntawv pov thawj zoo
Tag nrho batch traceability thiab ua tiav cov ntaub ntawv (COA, MSDS, HPLC)
Flexible mov: gram qauv mus rau tuj - qib xaj ntau
Kev xa tawm thoob ntiaj teb mus rau 70+ lub teb chaws nrog kev txhawb nqa tag nrho

Ntim Ntim, Shipping & Cia

Ntim: Cov hnab ntawv rau cov qauv thiab cov dej noo-cov ntaub ntawv pov thawj fiber ntau rau kev txiav txim ntau.
Custom Packaging: OEM labeling muaj.
Cov ntaub ntawv xa khoom: COA, MSDS / SDS, daim ntawv them nqi lag luam, cov ntawv ntim khoom thiab cov ntaub ntawv kev lis kev cai muaj raws li kev txiav txim siab.
Cia: Khaws nruj nreem kaw rau hauv qhov chaw txias, qhuav, lub teeb - tiv thaiv ib puag ncig. Lub neej txee: 24 lub hlis.
Kev tuav: Rau cov khoom siv raw khoom siv xwb; tsis yog rau kev tswj xyuas kev kho mob ncaj qha.

Cov lus nug nquag nug txog Closantel Sodium Powder

Q1: Closantel Sodium Powder yog dab tsi?

A: Cov ntsev ntsev ntawm closantel, hluavtaws salicylanilide anthelmintic siv rau daim siab fluke, ntshav- nqus nematodes thiab arthropod larvae hauv nyuj, yaj, tshis thiab camelids.

Q2: Tus lej CAS yog dab tsi?

A: 61438-64-0.

Q3: Closantel ua haujlwm li cas?

A: Nws uncouples mitochondrial oxidative phosphorylation hauv cov kab mob cab, inhibiting ATP synthesis thiab cuam tshuam lub zog metabolism. Nws kuj cuam tshuam kev thauj mus los ntawm daim nyias nyias thiab tuaj yeem cuam tshuam chitinase hauv cov kab mob cab.

Q4: Cov kab mob dab tsi closantel kho?

A: Cov kab mob siab (Fasciola hepatica, F. gigantica - cov neeg laus thiab cov neeg laus tsis paub qab hau), cov ntshav- nqus cov nematodes (Haemonchus contortus, nrog rau cov kab mob resistant), lungworms, eyeworms, warble fly larvae, nasal bots, mites, ticks.

Q5: Puas yog closantel zoo tiv thaiv kab mob?

A: Yog. Closantel tau pom 100% kev ua tau zoo tiv thaiv benzimidazole- tiv taus Haemonchus contortus thiab tseem ua haujlwm tawm tsam ntau yam ivermectin- tiv thaiv kev sib cais, vim nws cov txheej txheem sib txawv ntawm kev ua.

Q6: Cov ntaub ntawv twg yog muab rau txhua pawg?

A: Batch- tshwj xeeb COA, HPLC daim ntawv qhia, IR cov ntaub ntawv tus kheej, cov ntaub ntawv melting point, iodine cov ntsiab lus tsom xam, MSDS/SDS thiab cov ntaub ntawv xa tawm.

Q7: Dab tsi purity koj muab?

A: Standard Ntau dua lossis sib npaug rau 98% HPLC; raug batch tshwm sim 99%. Cov qib siab muaj nyob rau ntawm kev thov.

Q8: Kuv tuaj yeem yuav nws li cas los ntawm Tuam Tshoj?

A: HDM BIO khoom siv ntauClosantel Sodium hmoovnrog batch COA thiab thoob ntiaj teb kev txhawb nqa export.

Q9: Closantel Sodium Powder nqi ntau npaum li cas?

A: Tus nqi ntau yog nyob ntawm cov nqi sib txuas (nrog rau cov khoom siv iodine), purity / qib, kev tswj hwm kev tswj hwm, kev txiav txim ntim thiab kev xa khoom. Hu rau HDM BIO rau cov lus hais tam sim no.

Q10: Puas yog closantel muaj kev nyab xeeb?

A: Closantel muaj qhov nqaim kev nyab xeeb. Kev noj ntau dhau yuav ua rau pom kev tsis pom kev, qhov muag tsis pom kev thiab cov tsos mob ntawm lub paj hlwb. Siv nruj me ntsis raws li daim ntawv lo koob tshuaj raws li kws kho tsiaj saib xyuas, thiab saib xyuas lub sijhawm tshem tawm. Tsis yog rau kev tswj xyuas kev kho mob ncaj qha.