Retatrutide yog dab tsi thiab nws ua haujlwm li cas hauv 2026?

Retatrutide (CAS Registry Number: 2381089-83-}2) yog ib qho hluavtaws 39-amino acid peptide engineered ua triple receptor agonist. Nws yog structurally raws li ib haiv neeg GIP peptide qaum qaum, nrog lub hom phiaj amino acid hloov kho thiab ib tug C20 fatty diacid sab saw txuas mus rau nws ib nrab-lub neej mus rau kwv yees li 6 hnub, txhawb ib zaug ib lub lim tiam.

Nws tau tsim thiab tam sim no nyob rau hauv lig - theem 3 kev sim tshuaj. Raws li ntawm ib nrab xyoo 2026, nws tsis tau txais kev pom zoo rau kev siv tshuaj kho mob hauv ib cheeb tsam thoob ntiaj teb, thiab feem ntau yog siv hauv cov tshuaj R & D thiab API cov saw hlau.

Cov ntsiab lus tseem ceeb ntawm ib nrais muag:

• Chav Kawm Tshuaj: Triple receptor agonist peptide
• Cov ntsiab lus tseem ceeb: Kev rog rog, ntshav qab zib hom 2, MASH
• CAS Nr .: 2381089-83-2
• Ib nrab -lub neej: ~ 6 hnub
• Kev loj hlob theem: Theem 3
• Kev tswj hwm: Ib zaug- txhaj tshuaj subcutaneous txhua lub lim tiam

Retatrutideua hauj lwm los ntawm ib txhij ua kom peb lub ntsiab metabolic hormone receptors: GIP, GLP-1, thiab glucagon. Ua ke, peb txoj hauv kev no tswj hwm ob sab ntawm lub cev lub zog sib npaug sib npaug, ua tiav ob txoj kev tswj hwm ntawm lub zog noj thiab noj uas ib leeg / dual agonists tsis tuaj yeem sib tw:

• Txo qab los noj mov thiab caloric kom tsawg (ntawm GLP-1 thiab GIP kev ua ntawm hypothalamus): Txo cov zaub mov ntau dhau thiab kev siv calorie ntau dhau, ua lub hauv paus rau kev poob phaus.
• Kev txhim kho insulin rhiab heev thiab tawg rog (ntawm GIP kev txiav txim ntawm cov ntaub so ntswg adipose): Txo cov tshuaj insulin, ua kom cov rog subcutaneous thiab visceral decomposition, thiab txhim kho cov kab mob metabolic.
• Kev siv zog so kom txaus thiab lub siab rog oxidation (ntawm glucagon ua rau lub siab): Ua kom cov metabolism hauv basal, noj cov rog hauv siab, thiab tsis txhob poob phaus toj siab ntau nrog ib zaug - cov tshuaj noj

2026 Clinical Data Summary

Raws li lub Xya hli ntuj 2026, ob qhov tseem ceeb ntawm Theem 3 qhov kev sim tau tso tawm cov txiaj ntsig saum toj kawg nkaus lees paub qhov kev ua tau zoo tshaj plaws ntawm rettrutide thiab kev ruaj ntseg profile, teeb tsa qhov kev ua tau zoo tshiab rau cov tshuaj metabolic peptide:

THIUMPH-1

1. 2,339 tus neeg laus uas muaj rog / rog thiab hnyav -txog kev sib kis (tsis muaj ntshav qab zib)
2. 12mg koob tau tiav 28.3% qhov hnyav poob ntawm 80 lub lis piam
3. 65.3% ntawm cov neeg mob tau mus txog BMI qis dua 30 kg / m²
4. Txuas ntxiv ua raws- nce pom 30.3% qhov hnyav nruab nrab ntawm 104 lub lis piam hauv siab -BMI pawg, tsis muaj qhov ntsuas qhov hnyav

TRANSCEND-T2D-1 

• Cov neeg laus uas tswj tsis tau cov ntshav qab zib hom 2
• 12mg koob tau ua tiav 2.0% HbA1c txo qis thiab 16.8% qhov hnyav nruab nrab ntawm 40 lub lis piam

Kev ua tau zoo hauv xov xwm thiab kev txhim kho kev sib piv ntawm rettrutide thiab mainstream pom zoo metabolic peptides:

Retatrutide API Supply & Cov Txheej Txheem Zoo

High-purity rettrutide API yog tsim los ntawm cov khoom siv-theem peptide synthesis (SPPS), ua raws li ntau-pab HPLC purification thiab tag nrho cov kev tswj xyuas zoo. GMP- qib API yog qhov yuav tsum tau ua rau txhua qhov kev ua haujlwm kho mob ua ntej thiab kho mob, nrog rau kev lag luam nruj- tus qauv zoo rau kev siv tshuaj- qib ntawv.

Cov qauv zoo tseem ceeb rau kev siv tshuaj -qib rettrutide API:

• Yam tsawg kawg nkaus 98% HPLC purity (99% yuav tsum tau siv rau kev kho mob / kho mob)
• Tag nrho cov khoom siv -COA tshwj xeeb nrog LC-MS, endotoxin, cov hlau hnyav, thiab cov khoom hnyav hnyav
• Tsim nyob rau hauv ISO- ntawv pov thawj GMP- ua raws li cov chaw huv
• ruaj khov batch-rau-batch sib xws thiab scalable kg/ton-theem txhua xyoo muaj peev xwm

Q: Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm rettrutide nyob rau hauv poob phaus?

A:Retatrutide ua raws li triple GIP/GLP-1/glucagon agonist. GLP-1 thiab GIP txo qis qab los noj mov kom txo cov calories kom tsawg, GIP boosts insulin rhiab heev thiab rog decomposition, thiab glucagon nce cov metabolism hauv so thiab daim siab rog oxidation. Peb txoj kev sib xyaw ua ke tsim cov txiaj ntsig muaj rog ntau dua li cov tshuaj peptide ib leeg lossis ob lub hom phiaj, txhawb nqa tas mus li, toj siab tsis muaj qhov hnyav.

Q: Puas yog Retatrutide FDA pom zoo?

A:Raws li ntawm nruab nrab-2026, rettrutide tseem nyob rau theem 3 kev kho mob thiab tsis tau txais FDA lossis lwm yam kev pom zoo thoob ntiaj teb rau kev siv tshuaj kho mob. Tam sim no nws tsuas yog muaj rau cov kws tshuaj R & D thiab kev tsim khoom.

Q: Koj tuaj yeem poob qhov hnyav npaum li cas nrog rettrutide?

A:Hauv Theem 3 kev sim tshuaj, 12mg koob tshuaj rettrutide ua rau qhov hnyav poob ntawm 28.3% tshaj li 80 lub lis piam hauv cov neeg laus uas rog rog, ua tau zoo tshaj txhua qhov kev pom zoo GLP-1 thiab kev kho dual agonist. Cov txiaj ntsig ntawm tus kheej tuaj yeem sib txawv raws li BMI hauv qab thiab lub cev mob.

Q: Qhov txawv ntawm rettrutide thiab tirzepatide yog dab tsi?

A:Thawj qhov sib txawv yog cov hom phiaj receptor: tirzepatide yog ob GIP / GLP-1 agonist, thaum rettrutide yog triple GIP / GLP-1 / glucagon agonist. Qhov ntxiv glucagon receptor kev ua ub no nce kev siv hluav taws xob thiab roj oxidation, ua rau muaj kev poob phaus ntau dua hauv kev sim tshuaj.

Q: CAS tus lej rau rettrutide yog dab tsi?

A:CAS npe rau rettrutide yog 2381089-83-2.

Q: Kuv puas tuaj yeem yuav Retatrutide API rau kev tshawb fawb siv?

A:Yog lawm, GMP-qib rettrutide nyoos hmoov yog muaj los ntawm cov tsim nyog peptide API tuam ntxhab rau kev siv tshuaj R&D thiab kev tsim kho kev siv. Nws tsis yog npaj rau tus kheej siv tib neeg.

Nkag mus rau cov kev tshaj lij tshwj xeeb thiab cov kev pabcuam kev tsim kho kom haum rau koj cov R&D thiab cov txheej txheem ntau lawm:

• Download Clinical + Procurement Full Package- Ua kom tiav Phase 3 sim cov ntaub ntawv tshaj tawm + API daim ntawv teev cov qauv zoo
• Tau txais GMP Retatrutide API COA hauv 24 teev- Batch- cov ntaub ntawv tsim nyog tag nrho rau kev tshuaj xyuas qhov project thiab R&D ua ntaub ntawv
• Thov Tuam Tshoj Chaw Tsim Tshuaj Ntsuam Xyuas Daim Ntawv Qhia- Hoobkas tsim nyog, muaj peev xwm ntau lawm thiab GMP ua raws ntaub ntawv pov thawj
• Thov rau Kev Ntsuam Xyuas Kev Muag Khoom Loj & Kev Cai Quotation- Cov qauv kuaj dawb, kg / tuj- qib tus nqi ntau thiab cov khoom siv tshwj xeeb

Tsis lees paub

Phau ntawv qhia hub no yog rau cov ntaub ntawv xov xwm nkaus xwb thiab yog npaj tshwj xeeb rau kev lag luam kws tshuaj R&D thiab cov kws tshaj lij kev muag khoom. Retatrutide yog ib qho kev tshawb nrhiav tsis tau pom zoo rau kev siv tshuaj kho mob thoob ntiaj teb. Nws raug txwv tsis pub txhaj tshuaj rau tib neeg tus kheej lossis tawm ntawm - daim ntawv lo hnyav - poob tus kheej - kev tswj hwm. Tag nrho cov ntaub ntawv kho mob thiab cov ntaub ntawv zoo tau hais txog yog los ntawm kev tshaj tawm cov txiaj ntsig sim thiab thoob ntiaj teb ICH GMP cov qauv kev lag luam raws li nruab nrab-2026.