KPV Peptide
| Teb | Paub meej |
|---|---|
| Lub npe | L-Lysyl-L-prolyl-L- valine (Lys-Pro-Val) |
| Ib ntus | Lys-Pro-Val; Daim ntawv qhia txog lub davhlau ya nyob twg paub tseeb ntawm batch COA |
| CAS nr | 67727-97-3 rau daim ntawv teev npe dawb-acid; txheeb xyuas qhov tseeb ntawm daim ntawv molecular thiab cov ntaub ntawv batch |
| Cov mis mos molecular | C₁₆H₃₀N₄O₄ (dawb-acid form) |
| Molecular hnyav | 342.43 g / mol (dawb-acid form) |
| Peptide ntev | 3 amino acids (tripeptide) |
| -MSH kev sib raug zoo | C-terminal fragment, -MSH(11–13) |
| Yam khoom | Lyophilized hmoov (tseem); kev daws teeb meem los yog kev cai hom nyob ntawm tus neeg muag khoom |
| Npaj siv | Laboratory tshawb fawb; tshuaj pleev ib ce los yog lwm yam kev siv yuav tsum tau lub hom phiaj - kev tswj xyuas kev lag luam |
Tsab ntawv K, P thiab V txhais li cas?
KPVyog ib qho - tsab ntawv luv rau peb -amino-acid sequence:
- K=Lysine- ib qho yooj yim amino acid nrog plaub -carbon side chain terminating nyob rau hauv ib pawg amino. Hauv KPV, lysine ua rau muaj txiaj ntsig zoo ntawm lub cev pH thiab yog N- seem seem.
- P=Proline- ib qho cyclic amino acid uas nws cov saw hlau txuas rov qab mus rau peptide qaum, qhia txog kev sib haum xeeb. Proline zaum hauv nruab nrab ntawm KPV thiab txwv tsis pub peptide peb -dimensional shape.
- V=Valine- ib ceg - saw aliphatic amino acid. Hauv KPV, valine yog C-terminal residue thiab ua rau cov cim hydrophobic rau tripeptide.
Qhov kev txiav txim yog tsau. KPV txhais tau tias Lys-Pro-Val tshwj xeeb. VKP (Val-Lys-Pro) lossis KVP (Lys-Val-Pro) yog cov peptides sib txawv nrog cov khoom sib txawv ntawm physicochemical thiab yuav tsum tsis txhob raug kho zoo ib yam li KPV.
KPV cuam tshuam li cas rau -MSH?
-MSH yog 13-amino-acid endogenous melanocortin peptide nrog cov kab ke Ac-SYSMEHFRWGKPV-NH₂. Nws koom nrog melanocortin signaling los ntawm melanocortin receptors hauv ntau cov ntaub so ntswg. KPV sib raug rau peb qhov kawg amino-cov kua qaub seem, txoj haujlwm 11–13, feem ntau sau ua -MSH(11–13).
Ob qhov sib txawv tseem ceeb rau cov neeg yuav khoom thiab cov neeg tshawb nrhiav:
Fragment piv rau tag nrho peptide.KPV yog peb-amino- cov kua qaub ntawm -MSH, tsis yog tag nrho 13-amino-acid molecule. Cov teebmeem lom tau tshaj tawm rau tag nrho -ntev -MSH tsis tuaj yeem raug xa mus rau KPV.
Terminal thiab counter-ion form.KPV yog hais txog Lys-Pro-Val ib ntus, tab sis cov khoom lag luam tuaj yeem muab rau hauv ntau lub davhlau ya nyob twg lossis txee- cov ntawv ion nyob ntawm cov khoom specification. Cov neeg yuav khoom yuav tsum lees paub qhov tseeb ntawm daim ntawv molecular, qhov hnyav molecular thiab kev txheeb xyuas tus kheej ntawm cov ntaub ntawv tshwj xeeb -.
KPV Peptide Ua li cas?
KPV feem ntau yog tsim los ntawm cov khoom siv -theem peptide synthesis (SPPS), tus qauv txheej txheem rau luv synthetic peptides. Lub C-terminal residue yog txuas nrog cov khoom txhawb nqa, ua raws li cov voj voog rov qab ntawm N-terminal deprotection thiab amino-acid coupling los sib sau ua ke. Tom qab synthesis, peptide yog cleaved los ntawm cov resin nrog tshem tawm cov pab pawg neeg, purified raws li yuav tsum tau, lyophilized thiab analytically xyuas. Cov txheej txheem dav dav suav nrog:
- Resin loading / txuas ntawm C-terminal residue
- Kev tiv thaiv tsis tu ncua thiab amino-acid coupling
- Qhov kawg cleavage thiab tiv thaiv - pab pawg tshem tawm
- Kev ua kom huv, feem ntau los ntawm kev npaj RP-HPLC
- Lyophilization
- Kev txheeb xyuas tus kheej thiab kev ua kom huv huv (HPLC thiab LC-MS)
Cov cuab yeej tshwj xeeb, cov khoom lag luam, cov khoom sib txuas ua ke, cov xwm txheej cleavage thiab kev ua kom huv huv yog cov chaw tsim khoom - thiab batch- tshwj xeeb. Yog tsis muaj HDM cov ntaub ntawv pov thawj ntau lawm, nplooj ntawv no piav qhia txog txoj kev sib xyaw ua ke nkaus xwb thiab tsis hais txog cov txheej txheem ua tswv cuab.
KPV Kawm Txog Dab Tsi?
Tshaj tawm KPV kev tshawb fawb nthuav dav ntau cov lus qhia kev sim:
- Inflammatory -kev tshawb fawb qhia- KPV tau kawm nyob rau hauv cell thiab tsiaj qauv ntawm o, nrog rau kev ua hauj lwm tshuaj xyuas nws cov kev sib raug zoo rau lub dav -MSH melanocortin txoj kev.
- Epithelial- qauv cell- cov kev tshawb fawb tau siv cov kab mob epithelial thiab plab hnyuv los tshuaj xyuas KPV uptake thiab signaling teb.
- Keratinocyte kev nyuaj siab- 2025 txoj kev tshawb fawb tau tshuaj xyuas KPV hauv PM10- nthuav tawm tib neeg HaCaT keratinocytes thiab 3D daim tawv nqaij qauv, qhia txog cov koom haum nrog txo ROS, modulated MAPK/NF-κB signaling thiab qis cov cim inflammatory.
- Txoj hnyuv peptide thauj- KPV tau pom tias tau coj los ntawm plab hnyuv peptide thauj PepT1 hauv cov qauv kev sim, ib txoj hauv kev cuam tshuam rau kev tshawb fawb ntawm qhov ncauj peptide.
- Oxidative- qauv kev nyuaj siab- KPV tau raug tshuaj xyuas hauv cov qauv ntawm tes uas muaj cov pa oxygen reactive thiab oxidative kev puas tsuaj.
- Peptide-kev xa khoom- vim KPV yog ib qho tripeptide luv luv, nws tau siv los ua tus qauv substrate rau kev kawm peptide thauj, kev ruaj ntseg thiab kev tsim qauv.
Cov no yog cov lus qhia tshawb fawb, tsis tau tsim cov ntawv thov kho mob. Cov ntaub ntawv tshaj tawm feem ntau yog los ntawm cov xov tooj ntawm tes-raws li thiab cov qauv tsiaj.
Cov pov thawj tiag txhawb dab tsi?
| Hom pov thawj | Dab tsi Nws Yuav Qhia tau | Dab tsi Nws Qhia tsis tau |
|---|---|---|
| Hauv vitro | Cell - theem kev hloov thiab biomarker hloov | Tib neeg txoj kev kho mob |
| Tsiaj qauv | Cov lus teb raws li qhov kev sim uas tau teev tseg | Tib neeg kev nyab xeeb, kev ua tau zoo lossis kev siv tshuaj |
| Kev tshawb fawb tib neeg | Cov txiaj ntsig tau raws li kev tsim kho kho mob | Cov lus xaus dhau ntawm cov neeg kawm, koob tshuaj thiab cov ntsiab lus kawg |
| Kev thov kev lag luam | Khoom muag los yog npaj siab - siv lus | Kev ua tau zoo los yog kev nyab xeeb ntawm nws tus kheej |
Cov ntaub ntawv pov thawj tam sim no txhawb nqa kev soj ntsuam ntxiv ntawm KPV hauv inflammatory, oxidative -kev nyuaj siab thiab epithelial- qauv cell. Nws tsis tsim kom muaj kev kho mob zoo, kev noj zaub mov zoo rau tib neeg, lossis kev nyab xeeb ntev -. Txhua qib pov thawj teb cov lus nug sib txawv: hauv kev tshawb fawb hauv vitro tsim kom muaj txoj hauv kev tuaj yeem hloov kho raws li kev tswj hwm ntawm tes; kev tshawb fawb tsiaj tshawb nrhiav seb puas tuaj yeem pom muaj txiaj ntsig hauv cov kab mob uas muaj sia nyob raws li kev siv tshuaj; tib neeg kev tshawb fawb tsim kom pom seb qhov cuam tshuam puas tuaj yeem tshwm sim hauv cov neeg uas muaj lub zog tsim nyog. Kev thov kev lag luam, los ntawm qhov sib txawv, piav qhia txog qhov khoom muag thiab tsis yog hloov pauv rau ib qho ntawm cov saum toj no. Txoj hauv kev sib tw no pab cov neeg yuav khoom paub qhov txawv ntawm kev tshawb fawb txog kev siv tshuab thiab tsim cov khoom siv kho mob.
Puas yog KPV cov khoom xyaw tshuaj pleev ib ce lossis tshawb fawb Peptide?
KPV feem ntau yog sib tham thiab muab los ua kev tshawb fawb peptide. Ua ntej muab KPV ua cov khoom siv tshuaj pleev ib ce, cov neeg yuav khoom yuav tsum txheeb xyuas cov khoom muaj tam sim no kev tswj hwm thiab cov khoom lag luam hauv lub khw tshwj xeeb, suav nrog cov khoom muaj feem xyuam -npe, kev nyab xeeb- kev ntsuas thiab cov khoom lag luam- ceeb toom yuav tsum tau ua. Qhov no txawv KPV los ntawm qhov zoo- tsim cov peptides kom zoo nkauj xws li Acetyl Hexapeptide-8 lossis Palmitoyl Pentapeptide-4, uas tau lees paub INCI cov npe thiab feem ntau teev nyob rau hauv cov khoom siv tshuaj pleev ib ce.
HDM's KPV cov ntsiab lus yog vim li no nyob ib puag ncig kev tshawb fawb hauv chaw soj nstuam siv thiab raw- cov ntaub ntawv tus kheej, tsis nyob ib ncig ntawm cov khoom tiav - cov khoom thov kom zoo nkauj.
FAQ
Lub npe tag nrho ntawm KPV yog dab tsi?
KPV yog L-Lysyl-L-prolyl-L-valine, tripeptide nrog cov kab ke Lys-Pro-Val.
Cov amino-acid sequence ntawm KPV yog dab tsi?
Cov kab ke yog Lys-Pro-Val. Daim ntawv qhia davhlau ya nyob twg thiab qhov hnyav molecular yuav tsum tau lees paub nyob rau hauv batch-cov ntaub ntawv tshwj xeeb.
Puas yog KPV zoo ib yam li -MSH?
Tsis yog. KPV sib raug rau txoj haujlwm 11–13 (C-terminal tripeptide) ntawm -MSH, tab sis nws yog ib feem thiab yuav tsum tsis txhob raug kho raws li kev ua haujlwm sib npaug rau tag nrho 13-amino-acid peptide.
Puas yog KPV tshwm sim lossis hluavtaws?
KPV ib ntus tshwm sim ib txwm ua raws li C- ntu ntu ntawm -MSH, tab sis cov khoom lag luam KPV cov khoom siv feem ntau yog tsim los ntawm cov khoom siv -theem peptide synthesis thiab muab los ua kev tshawb fawb peptide.
Puas yog KPV pom zoo rau tib neeg siv?
Tsis yog. KPV yog kev tshawb fawb peptide; cov pov thawj luam tawm yog tswj hwm los ntawm cov qauv ntawm tes thiab tsiaj txhu, thiab tsis muaj kev qhia txog kev kho mob tib neeg. Kev siv tib neeg yuav tsum muaj kev tswj hwm thiab kev saib xyuas kev kho mob tsim nyog.
Nrhiav rau KPV peptide hmoov rau kev soj ntsuam kuaj?HDM Biotech muab batch-COA tshwj xeeb, cov ntaub ntawv txheeb xyuas, cov qauv kev txhawb nqa thiab kev xaiv ntau yam raws li cov khoom lag luam paub tseeb.
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Cov ntaub ntawv
- Sung J, Ju S-Y, Park S, Jung W-K, Je J-Y, Lee S-J. Lysine-Proline-Valine peptide txo cov plua plav zoo-induced keratinocyte apoptosis thiab o los ntawm kev tswj oxidative kev nyuaj siab thiab modulating MAPK/NF-κB txoj kev. Tissue & Cell. 2025;95:102837. DOI: 10.1016/j.tice.2025.102837. PIB: 40073467.
- Tau txais SJ, Schiöth HB, Perretti M. Kev txiav tawm ntawm cov tshuaj tiv thaiv - cov nyhuv inflammatory ntawm cov tub ntxhais thiab C-terminal (KPV) alpha-melanocyte- txhawb nqa cov tshuaj peptides. Phau ntawv Journal of Pharmacology and Experimental Therapeutics. 2003;306(2):631–637. PIB: 12750433.
- Elliott RJ, Szabo M, Wagner MJ, Kemp EH, MacNeil S, Haycock JW. alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV thiab adrenocorticotropic hormone signaling nyob rau hauv tib neeg keratinocyte hlwb. Phau ntawv Journal of Investigative Dermatology. 2004;122(4):1010–1019. PIB: 151020922.
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake txo cov plab hnyuv. Gastroenterology. 2008;134(1):166–178. PIB: 18061177.
- PubChem. Lys-Pro-Val (CID 125672). Cov mis mos molecular C₁₆H₃₀N₄O₄; molecular hnyav 342.43 g / mol. Nkag mus rau 2026.