Palmitoyl Tetrapeptide-20 yog dab tsi? Kev siv, Science thiab kev siv tshuaj pleev ib ce

Teb ceev: Palmitoyl Tetrapeptide-20 yog dab tsi?

Palmitoyl Tetrapeptide-20 (PTP20) yog ib qho hluavtaws, palmitoylated cosmetic peptide siv hauv kev tu plaub hau thiab tawv taub hau. Nws yog qhov paub zoo tshaj plaws rau kev tshawb fawb txog kev nyiam cov plaub hau pigmentation: nws tau tsim los ua ib qho agonist ntawm -melanocyte-stimulating hormone ( -MSH), tsom rau cov pigmentation-txog txoj hauv kev xws li MC1-R signaling. PTP20 yog cov khoom siv tshuaj pleev ib ce rau kev tsim kho, tsis yog tshuaj thiab tsis yog xim plaub hau.

Palmitoyl Tetrapeptide-20 ntawm ib sab

Palmitoylation yog hais txog kev sib txuas ntawm palmitic acid (saturated C16 fatty acid) saw rau peptide. HauvPalmitoyl Tetrapeptide-20, qhov seem ntawm palmitoyl txuas nrog luv luv tetrapeptide sib lawv liag. Qhov kev hloov kho no muaj nyob rau hauv cov tshuaj pleev ib ce peptides vim hais tias cov rog rog ua rau cov molecule affinity rau lipid- nplua nuj ib puag ncig, uas tuaj yeem cuam tshuam kev ruaj ntseg thiab kev coj tus cwj pwm hauv cov roj- dej tshuab thiab lipid-raws li formulations.

Hauv kev xyaum, palmitoylation cuam tshuam li cas cov peptide coj hauv cov qauv: nws solubility, nws compatibility nrog roj thiab emulsifiers, thiab nws partitioning ntawm daim tawv nqaij thiab tawv taub hau nto. Ntau cov peptides luv luv yog txwv tsis pub hydrophilic thiab luv luv - nyob ntawm lipid- cov chaw nplua nuj, yog li kev sib txuas ntawm cov saw roj yog ib qho kev tsim qauv tsim los txhim kho kev faib ua cov roj theem thiab lipid daim nyias nyias. Lub npe hu ua convention yog ncaj nraim: "palmitoyl" qhia txog cov roj fatty, thiab "tetrapeptide-20" txheeb xyuas cov peptide ib ntus hauv INCI system, tib lub logic siv thoob plaws palmitoyl-peptide tsev neeg hauv tshuaj pleev ib ce. Nws yog ib qho tseem ceeb uas yuav tau piav qhia meej txog qhov no: palmitoylation tuaj yeem txhawb kev sib raug zoo rau lipid-nplua nuj ib puag ncig; nws tsis yog nws tus kheej lav nkag mus ntawm cov plaub hau follicle lossis tawv taub hau.

Cov plaub hau xim yog tsim los ntawm melanocytes nyob rau hauv cov plaub hau qhov muag teev. Thaum cov plaub hau tshiab, melanocytes synthesize melanin thiab hloov mus rau keratinocytes uas tsim cov plaub hau ncej. Cov plaub hau greying (canities) yog txuam nrog txo melanin thiab nce oxidative kev nyuaj siab nyob rau hauv cov plaub hau follicle thiab ncej. Vim tias cov xim pleev xim tau muab tso rau hauv cov ntaub ntawv plaub hau, kev siv cov qauv feem ntau yog tham txog hauv cov ntsiab lus ntawm cov plaub hau loj hlob tshiab es tsis yog cov plaub hau uas twb muaj lawm.

PTP20 tau kawm txog cov txheej txheem no. Kev tshawb fawb luam tawm piav qhia tias nws yog ib qho agonist ntawm -melanocyte- stimulating hormone ( -MSH), txuas nrog melanocortin -1 receptor (MC1-R) txoj kev koom nrog hauv melanin synthesis. Kev tshawb fawb kuj tau tshuaj xyuas nws txoj kev sib raug zoo nrog oxidative-stress markers, nrog rau catalase thiab intracellular hydrogen peroxide. Cov txheej txheem no piav qhia tias yog vim li cas PTP20 tau nyiam cov tshuaj pleev ib ce uas tsom rau cov plaub hau greying.

PTP20 feem ntau yog muab tso rau hauv kev tawm mus - ntawm hom kev tu plaub hau thiab tawv taub hau:

• Scalp serums
• Anti-cov plaub hau grey essences
• Tawm - ntawm tonics
• Tshaj tawm - kev saib xyuas xim xim
• Cov plaub hau ntuj- xim kho cov qauv

Tawm hauv - ntawm cov hom ntawv muab kev sib cuag nrog tawv taub hau, yog vim li cas lawv thiaj li muaj cov neeg nqa khoom rau qis - koob tshuaj active xws li peptides. Yaug-tawm hom ntawv tuaj yeem ua tau tab sis yuav tsum tau xav txog lub sijhawm sib cuag, nquag nquag thiab tsim qauv tsim. Vim hais tias peptides feem ntau yog siv nyob rau hauv tsawg concentrations, lub tsheb thiab daim ntawv thov hom ntawv tseem ceeb npaum li lub active nws tus kheej.

Peb pawg khoom feem ntau tsis meej pem:

• Raw hmoov: unformulated peptide khoom muab rau manufacturers; xav tau kev ntsuas ntsuas thiab ntsuas ntsuas.
• Ua ntej - diluted tov: peptide twb yaj nyob rau hauv ib tug cab kuj; yooj yim dua rau koob, tab sis tus neeg yuav khoom yuav tsum xam cov ntsiab lus peptide tiag tiag.
• Commercial complexes: formulation systems uas sib txuas cov peptide nrog cov cab kuj. Greyverse ™ yog cov khoom lag luam uas muaj npe INCI yog Glycerin (thiab) Dej (thiab) Palmitoyl Tetrapeptide-20 Amide.

Cov ntawv no tsis hnyav - hloov pauv tau. Tib lub nominal hnyav ntawm hmoov, tov thiab complex muaj ntau npaum li cas ntawm active peptide. Qhov tseem ceeb tshaj plaws rau kev noj tshuaj yog cov ntsiab lus peptide tiag tiag, tsis yog lub raj mis hnyav. Ib ntus, daim ntawv davhlau ya nyob twg thiab cov kev xav tau siab yuav tsum tau lees paub ua ntej muab kev sib piv.

Tsis yog. PTP20 yog positioned feem ntau rau cov plaub hau xim thiab grey -kev saib xyuas dawb, thiab tau kawm txog kev pigmentation-txog txoj hauv kev. Nws yuav tsum tsis txhob ua lag luam raws li kev kho plaub hau. Nws txoj kev tshawb fawb tsom mus rau cov plaub hau pigmentation thiab oxidative-kev nyuaj siab-txog txoj hauv kev hauv cov hauv paus plaub hau, tsis yog plaub hau- kev loj hlob stimulation. Ua kom ob pawg no sib cais kom tsis txhob muaj kev thov ntau dhau.

Ua ntej siv PTP20 nyob rau hauv ib tug formulation, paub meej tias:

• Tag nrho peptide ib ntus thiab daim ntawv davhlau ya nyob twg (peptide dawb, amide lossis ntsev)
• Lub hauv paus tseem ceeb thiab cov ntsiab lus peptide
• Solubility hauv lub tsheb npaj
• Compatibility nrog roj, emulsifiers thiab lwm yam actives
• Cwj pwm ntawm kev ua haujlwm kub
• pH ntau thiab stability
• Kev khaws cia thiab microbial xav tau
• Kev ntsuas kev ruaj ntseg hauv cov qauv kawg

Palmitoyl Tetrapeptide-20 ua dab tsi?

Nws yog cov tshuaj pleev ib ce peptide kawm txog kev cuam tshuam rau cov plaub hau pigmentation-txog txoj hauv kev, suav nrog melanogenesis thiab oxidative-kev nyuaj siab- ntsig txog cov txheej txheem. Nws yog ib qho khoom xyaw rau kev tsim kho, tsis yog tshuaj los yog xim.

Puas yog xim xim?

Tsis yog. Nws tsis xim cov plaub hau ncej. Nws tau kawm txog kev pigmentation-txoj kev cuam tshuam hauv cov qauv tshuaj pleev ib ce.

Nws puas ua haujlwm ntawm cov plaub hau dawb kiag li?

Muaj kev tshawb fawb koom nrog cov neeg tuaj yeem pab dawb nrog qhov ntxov ntxov ntxov greying thiab txwv hauv qhov ntsuas. Tsis muaj lub luag haujlwm thov hais tias nws kho cov plaub hau dawb tag nrho.

Dab tsi yog qhov txawv ntawm PTP20 hmoov thiab tshuaj?

Hmoov yog cov khoom siv peptide unformulated; cov tshuaj yog peptide ua ntej-kua rau hauv cov cab kuj. Lawv muaj qhov sib txawv active concentrations thiab tsis tuaj yeem hloov los ntawm qhov hnyav.

Puas yog Greyverse ™ lwm lub npe rau txhua PTP20 raw khoom?

No. Greyverse ™ yog ib hom tshuaj uas muaj npe INCI suav nrog Palmitoyl Tetrapeptide-20 Amide, glycerin thiab dej. Generic Palmitoyl Tetrapeptide-20 hmoov thiab Palmitoyl Tetrapeptide-20 Amide hmoov yog cov khoom sib txawv thiab yuav tsum tsis txhob raug kho raws li kev sib hloov.

1. Almeida Scalvino S, et al. Kev ua tau zoo ntawm tus agonist ntawm -MSH, lub palmitoyl tetrapeptide-20, hauv cov plaub hau pigmentation. International Journal of Cosmetic Science. 2018;40(5):516–524.
2. PubMed - Palmitoyl Tetrapeptide-20 cov plaub hau pigmentation kawm, PMID 30222197.
3. COSMILE Europe - Palmitoyl Tetrapeptide-20 cov ntaub ntawv tshuaj pleev ib ce.
4. Clariant / Lucas Meyer Tshuaj pleev ib ce - Greyverse ™ cov ntaub ntawv khoom.

Nrhiav rau Palmitoyl Tetrapeptide-20 hmoov rau kev tshawb fawb tshuaj pleev ib ce? HDM Biotech muab batch-specific COA, analytical documentation, sample support and bulk supply options as the confirm products specification.

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